Atherogenic lipid markers and testosterone levels in Nigerian men with prostate disorders

Duru, Romanda; Njoku, O. U.; Maduka, Ignatius C; Ugonabo, Martin C; Ugwuene, F. O

doi:10.21276/apjhs.2015.2.2.9

Cited by 3 publications

(3 citation statements)

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“…However, a significant (p < 0.05) reduction in total cholesterol, triacylglycerol and low density lipoprotein concentrations, and an elevation in high density lipoprotein concentration were observed upon treatment of BPH-induced rats with extracts (Table 6). Studies have shown an association among dyslipidemia, obesity and BPH (Nandeesha et al 2006;Tewari et al 2011;, which represents potential risk factors in BPH (Oh et al 2007;Liu et al 2010;Duru et al 2015). Our result suggests that the extract showed some anti-hyperlipidemic and modulatory effects on dyslipidemia induced by BPH.…”

Section: Effects Of Crude Methanol Extract Of Zapoteca Portoricensis supporting

confidence: 52%

Zapoteca portoricensisroot crude methanol extract and its fractions normalizes aberrations associated with benign prostatic hyperplasia in rats

et al. 2020

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This study investigated the application of crude methanol extract (CME) of Zapoteca portoricensis root and its methanol (MF) and ethyl acetate (EAF) fractions in managing benign prostatic hyperplasia (BPH). Forty-five albino rats (180-200 g) were divided into nine groups of five rats each: Group 1 served as normal control. BPH was induced in groups 2-9 using dihydrotestosterone and estradiol. Group 2 served as BPH-control and group 3 was dutasteride-treated. Groups 4 and 5, 6 and 7, and 8 and 9 were respectively treated with 200 and 400 mg/kg/d b.w. of CME, 200 and 400 mg/kg/d b.w. of MF, and 200 and 400 mg/kg/d b.w. of EAF, respectively for 14 days orally. The effects of the extracts on the hematological and biochemical indices of the rats were assessed. At 400 mg/kg/d b.w, p.o. using a gavage, CME, MF and EAF decreased prostatic specific antigen by 55.91%, 57.54% and 56.75%, respectively comparable to 58.80% by dutasteride (an indication of improved prostate status). The extracts also restored BPH-modified hematological and biochemical status of BPHinduced-extracts-treated rats compared to BPH-control. These findings suggest that Z. portoricensis root extracts normalize aberrations associated with BPH and may justify the plant's folkloric use in the management of BPH.

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Section: Effects Of Crude Methanol Extract Of Zapoteca Portoricensis supporting

confidence: 52%

Zapoteca portoricensisroot crude methanol extract and its fractions normalizes aberrations associated with benign prostatic hyperplasia in rats

et al. 2020

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“…High density lipoprotein in contrast to the TAG, TC and LDL was elevated significantly in the standard and the EECSL administered groups in comparison to the untreated control. Dyslipidemia has a link to metabolic syndrome and invariable exposes one to BPH (Liu et al, 2010;Duru et al, 2015). However, treatment with different doses of EECSL attenuated the progression of BPH as observed in this study.…”

Section: Effect Of Eecsl On Lipid Profilesupporting

confidence: 46%

Ethanol Extract of <em>Cassia</em> <em>sieberiana</em> Leaves Ameliorates deviances associated with Benign Prostatic Hyperplasia in Rats

Anaduaka

Ekeyi

Uchendu

2020

Proceedings of the 1st International E-Conference on Antioxidants in Health and Disease

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This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats (120-160 g) were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for twenty-one days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300 and 500 mg/kg of EECSL respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST) alanine aminotransferase (ALT) whereas an elevation in High density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrograph showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exert potent on BPH, hypolipidaemic and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.

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“…High-density lipoprotein in contrast to the TAG, TC, and LDL was elevated significantly in the standard and the EECSL administered groups in comparison to the untreated control. Dyslipidemia has a link to metabolic syndrome and invariable exposes one to BPH (Liu et al 2010;Duru et al 2015), which represents potential risk factors in BPH (Tewari et al 2011). Our result suggests that the extract showed some anti-hyperlipidemic and modulatory effects on dyslipidemia induced by BPH.…”

Section: Effect Of Eecsl On Lipid Profilementioning

confidence: 50%

Ethanol extract of Cassia sieberiana leaves ameliorates deviances associated with benign prostatic hyperplasia in rats

et al. 2021

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This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats of 11-12 weeks old weighing 120-160 g were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for 21 days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300, and 500 mg/kg of EECSL, respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate-specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), lowdensity lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) whereas an elevation in high-density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrographs showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exerts potent on BPH, hypolipidaemic, and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.

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Atherogenic lipid markers and testosterone levels in Nigerian men with prostate disorders

Cited by 3 publications

References 0 publications

Zapoteca portoricensisroot crude methanol extract and its fractions normalizes aberrations associated with benign prostatic hyperplasia in rats

Zapoteca portoricensisroot crude methanol extract and its fractions normalizes aberrations associated with benign prostatic hyperplasia in rats

Ethanol Extract of <em>Cassia</em> <em>sieberiana</em> Leaves Ameliorates deviances associated with Benign Prostatic Hyperplasia in Rats

Ethanol extract of Cassia sieberiana leaves ameliorates deviances associated with benign prostatic hyperplasia in rats

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