Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study

Abstract

Background Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. Methods Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. Results A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. Conclusions AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males.

The Association of Triglyceride Glucose index for Coronary Artery Disease in Postmenopausal Women

“… 20 In previous study, AIP was positively related to the severity of CAD in elderly individuals and was superior to other lipid profiles. 21 So we compared the differences between AIP and TyG for coronary artery disease in postmenopausal women.In addition, Wang et al demonstrated that the AIP, as a biomarker, assists in the prevention of CAD in the Chinese population. 12 Guo et al and Wu et al observed that AIP could be a powerful independent predictor of CAD risk in postmenopausal women.…”

Prognostication of Incidence and Severity of Ischemic Stroke in Hot Dry Climate From Environmental and Non-Environmental Predictors

“…Atherogenic index (AI), when elevated, is a marker of early atherosclerosis [119], [120]. Patients with IS may suffer from intracranial atherosclerosis that worsens IS severity and outcomes [121], [122].…”

The predictive value of nontraditional lipid parameters for intracranial and extracranial atherosclerotic stenosis: a hospital-based observational study in China

“…SdLDL-C has been listed as a potential biomarker of cardiovascular disease [ 23 ]. Studies have found that AIP is a novel marker of cardiovascular disease [ 24 , 25 ] and may be superior to traditional lipid parameters [ 26 – 28 ]. Nevertheless, only a few studies have been conducted regarding the association between AIP and intracranial or extracranial atherosclerotic stenosis; the predictive value remains unclear for intracranial atherosclerotic stenosis [ 29 , 30 ].…”