Atherogenic index of plasma and atherogenic coefficient are increased in major depression and bipolar disorder, especially when comorbid with tobacco use disorder

Nunes, Sandra Odebrecht Vargas; Melo, Luiz Gustavo Piccoli de; Castro, Márcia Regina Pizzo de; Barbosa, Décio Sabbatini; Vargas, Heber Odebrecht; Berk, Michael; Maes, Michael

doi:10.1016/j.jad.2014.09.038

Cited by 85 publications

(62 citation statements)

References 39 publications

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“…In women with postmenopausal osteoporosis, HRQoL subdomains, including pain and mental and social functions, correlate with NO levels and antioxidant enzyme activities, but not MDA . Increased MDA levels are detected in MDD, BD, patients with prior suicidal attempts, severe depression, TUD, and metabolic syndrome, while increased levels of AOPP are detected in suicide, major depression, and prenatal depression . Increased MDA and AOPP levels are oxidative damage biomarkers, which may cause (neuro)degenerative processes including arteriosclerosis and neurodegeneration, which both may be linked to lowered HRQoL scores.…”

Section: Discussionmentioning

confidence: 99%

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Lowered quality of life in mood disorders is associated with increased neuro‐oxidative stress and basal thyroid‐stimulating hormone levels and use of anticonvulsant mood stabilizers

Nunes

Maes

Roomruangwong

et al. 2018

Evaluation Clinical Practice

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Section: Discussionmentioning

confidence: 99%

“…Blood was sampled at 8.00 am after an overnight fast for the assay of biomarkers. The assays have been described previously and are shown in Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Lowered quality of life in mood disorders is associated with increased neuro‐oxidative stress and basal thyroid‐stimulating hormone levels and use of anticonvulsant mood stabilizers

Nunes

Maes

Roomruangwong

et al. 2018

Evaluation Clinical Practice

Self Cite

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“…Some studies reported raised TG in depression(e.g. [42][43][44][45] ), but meta-analysis on the topic is lacking. Of note, a prospective study in Finnish young adults showed that steeply rising TG levels throughout childhood and adulthood was associated with increased DS in adulthood 43 , consistent with the present finding of a causal role of TG in the development of DS.…”

Section: Discussionmentioning

confidence: 99%

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

Cheng

Chau

2018

Preprint

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AbstractBackgroundThe etiology of depression remains poorly understood. Changes in blood lipid levels were reported to be associated with depression and suicide, however study findings were mixed.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between blood lipids and depression phenotypes, based on large-scale GWAS summary statistics (N=188,577/480,359 for lipid/depression traits respectively). Five depression-related phenotypes were included, namely major depressive disorder (MDD; from PGC), depressive symptoms (DS; from SSGAC), longest duration and number of episodes of low mood, and history of deliberate self-harm (DSH)/suicide (from UK Biobank). MR was conducted with inverse-variance weighted (MR-IVW), Egger and Generalized Summary-data-based MR(GSMR) methods.ResultsThere was consistent evidence that triglyceride (TG) is causally associated with DS (MR-IVW beta for one-SD increase in TG=0.0346, 95% CI=0.0114-0.0578), supported by MR-IVW and GSMR and multiple r2 clumping thresholds. We also observed relatively consistent associations of TG with DSH/suicide (MR-Egger OR= 2.514, CI: 1.579-4.003). There was moderate evidence for positive associations of TG with MDD and the number of episodes of low mood. For HDL-c, we observed moderate evidence for causal associations with DS and MDD. LDL-c and TC did not show robust causal relationships with depression phenotypes, except for weak evidence that LDL-c is inversely related to DSH/suicide. We did not detect significant associations when depression phenotypes were treated as exposures.ConclusionsThis study provides evidence to a causal relationship between TG, and to a lesser extent, altered cholesterol levels with depression phenotypes. Further studies on its mechanistic basis and the effects of lipid-lowering therapies are warranted.

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“…BMI exhibited the greatest effect on AIP (PR: 3.76, 95% CI: 3.27–4.32), followed by the FPG level, TC level, BP level, diet score, smoking status, and physical activity, after adjustment for covariates. Epidemiological studies have shown associations of BMI, FPG, TC, diet, BP, physical activity, and smoking with AIP (either increased TG or decreased HDL) [22,23,29,33,34]. An inverse gradient relationship existed between the number of ideal CVH metrics and the prevalence of high AIP.…”

Section: Discussionmentioning

confidence: 99%

The Association of Ideal Cardiovascular Health and Atherogenic Index of Plasma in Rural Population: A Cross-Sectional Study from Northeast China

Guo

et al. 2016

IJERPH

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In 2010, the American Heart Association has proposed a new concept “ideal cardiovascular health” (CVH) based on seven CVH metrics: smoking, body mass index, physical activity, diet score, total cholesterol, blood pressure, and fasting plasma glucose. We aimed to determine the association of CVH with atherogenic index of plasma (AIP), a strong marker for atherosclerosis (AS). This cross-sectional study was conducted in the rural areas of northeast China and 11,113 middle-aged subjects were enrolled. Seven CVH metrics were classified into ideal, intermediate, and poor groups. AIP was calculated as log (TG/HDL) (triglycerides/high-density lipoprotein cholesterol). AIP > 0.21 was classified into the high AIP group and served as dependent variable. All seven CVH metrics were correlated with AIP. A gradient relationship between the number of poor CVH metrics and the prevalence of high AIP existed. Log binomial regression analysis showed that compared to those with five to seven ideal CVH metrics, individuals with four, three, two, one, and no ideal CVH metrics had 1.67, 2.66, 4.00, 5.30 and 6.50 times higher prevalence for high AIP. The subjects with poor CVH status had 2.73 times higher prevalence for high AIP. We found an inversely gradient relationship between the number of ideal CVH metrics and lower prevalence of high AIP.

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Atherogenic index of plasma and atherogenic coefficient are increased in major depression and bipolar disorder, especially when comorbid with tobacco use disorder

Cited by 85 publications

References 39 publications

Lowered quality of life in mood disorders is associated with increased neuro‐oxidative stress and basal thyroid‐stimulating hormone levels and use of anticonvulsant mood stabilizers

Lowered quality of life in mood disorders is associated with increased neuro‐oxidative stress and basal thyroid‐stimulating hormone levels and use of anticonvulsant mood stabilizers

Causal relationships between blood lipids and depression phenotypes: A Mendelian randomization analysis

The Association of Ideal Cardiovascular Health and Atherogenic Index of Plasma in Rural Population: A Cross-Sectional Study from Northeast China

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