Atherogenic Index of Plasma and Anthropometric Measurements among Osteoporotic Postmenopausal Sudanese Women: Possible Risk for Cardiovascular Disease

Elmugadam, Abdelgadir; Elfadil, Ghada A.; Hamad, Abdalrahman Ismail; Shikieri, Ahlam Badreldin El; Aledrissy, Mawahib; Altayb, Hisham N.

doi:10.1155/2022/1545127

Cited by 2 publications

(3 citation statements)

References 45 publications

(54 reference statements)

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“…Several studies have shown that age strongly influences the AIP and BMD ( 52 , 53 ). Our results were inconsistent with those of previous studies that found a negative association between the AIP and BMD in postmenopausal women ( 22 – 24 ). Through comparison, we found that it might be caused by differences in the study design, ethnic characteristics, measurement sites, etc.…”

Section: Discussioncontrasting

confidence: 99%

“…In Sudanese women, Elmugadam et al. found that the AIP was positively associated with the risk of OP in postmenopausal women ( 24 ). Our findings were similar to those of previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…There is growing evidence that there is a biological link between lipid and bone metabolism, and that the disturbance of lipid metabolism can directly affect bone formation and absorption, thereby affecting the strength of bone ( 20 , 21 ). Only a few epidemiological studies have investigated the relationship between AIP and BMD in the population, and these studies have found an inverse association ( 22 – 24 ). On the one hand, existing studies are limited to special postmenopausal population, and the association of the whole female population is not clear; on the other hand, the nonlinear association between AIP and BMD has not been deeply explored to find out the threshold of action, which is of great significance for clinical application.…”

Section: Introductionmentioning

confidence: 99%

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Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)

He,

Chen,

Liang

et al. 2024

Front. Endocrinol.

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BackgroundStudies on the relationship between the atherogenic index of plasma (AIP) and bone mineral density (BMD) among adult women in the United States are limited. The purpose of this study was to explore this association using a sizable, nationally representative sample.MethodsData from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES) were used in this observational study. The AIP was computed as log10 (triglycerides/high-density lipoprotein cholesterol). Total BMD was measured via dual-energy X-ray densitometry. We constructed multiple linear regression models to evaluate the correlation between the AIP and BMD. The non-linear relationship was characterized by smooth curve fitting and generalized additive models. We also conducted subgroup and interaction analyses.ResultsIn this study, we included 2,362 adult women with a mean age of 38.13 ± 12.42 years. The results of multiple linear regression analysis, the AIP and total BMD showed a negative association (β = −0.021, 95%CI: −0.037, −0.006). The curve fitting analysis and threshold effect analysis showed a non-linear relationship between the two variables, and the inflection point of the AIP was found to be -0.61. The total BMD decreased significantly when the AIP reached this value (β = −0.03, 95%CI: −0.04, −0.01). The results of the subgroup analysis showed that AIP and total BMD had a strong negative relationship in participants who were below 45 years old (β = -0.023; 95% CI: -0.041, -0.004), overweight (BMI ≥ 25 kg/m2) (β = -0.022; 95% CI: -0.041, -0.002), had a higher education level (β = -0.025; 95% CI: -0.044, -0.006), and had no partners (β = -0.014; 95% CI: -0.06, -0.009).ConclusionsWe found a negative correlation between the AIP and total BMD. Clinicians should pay attention to patients with high AIP, which might indicate a low BMD and has reference significance in preventing osteoporosis.

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confidence: 99%

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confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)

He,

Chen,

Liang

et al. 2024

Front. Endocrinol.

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Cross-talk between oxidative stress and lipid metabolism regulators reveals molecular clusters and immunological characterization in polycystic ovarian syndrome

Tan,

Huang,

et al. 2024

Lipids Health Dis

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Background Changes in the oxidative stress and lipid metabolism (OSLM) pathways play important roles in polycystic ovarian syndrome (PCOS) pathogenesis and development. Consequently, a systematic analysis of genes related to OSLM was conducted to identify molecular clusters and explore new biomarkers that are helpful for the diagnostic of PCOS. Methods Gene expression and clinical data from 22 PCOS women and 14 normal women were obtained from the GEO database (GSE34526, GSE95728, and GSE106724). Consensus clustering identified OSLM-related molecular clusters, and WGCNA revealed co-expression patterns. The immune microenvironment was quantitatively assessed utilizing the CIBERSORT algorithm. Multiple machine learning models and connectivity map analyses were subsequently applied to explore potential biomarkers for PCOS, and nomograms were employed to develop a predictive multigene model of PCOS. Finally, the OSLM status of PCOS and the hub genes expression profiles were preliminarily verified using TUNEL, qRT‒PCR, western blot, and IHC assays in a PCOS mouse model. Results 19 differential expression genes (DEGs) related to OSLM were identified. Based on 19 DEGs that were strongly influenced by OSLM, PCOS patients were stratified into two distinct clusters, designated Cluster 1 and Cluster 2. Distinct differences in the immune cell proportions existed in normal and two PCOS clusters. The random forest showed the best results, with the least cross-entropy and the utmost AUC (cross-entropy: 0.111 AUC: 0.960). Among the 19 OSLM-related genes, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 were identified by a Bayesian network and had a good fit with PCOS disease risk by the nomogram (AUC: 0.990 CI: 0.968–1.000). TUNEL assays revealed more severe DNA damage within the ovarian granule cells of PCOS mice than in those of normal mice ( P < 0.001). The RNA and protein expression levels of the five hub genes were significantly elevated in PCOS mice, which was consistent with the results of the bioinformatics analyses. Conclusion A novel predictive model was constructed for PCOS patients and five hub genes were identified as potential biomarkers to offer novel insights into clinical diagnostic strategies for PCOS. Supplementary Information The online version contains supplementary material available at 10.1186/s12944-024-02237-3.

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Atherogenic Index of Plasma and Anthropometric Measurements among Osteoporotic Postmenopausal Sudanese Women: Possible Risk for Cardiovascular Disease

Cited by 2 publications

References 45 publications

Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)

Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)

Cross-talk between oxidative stress and lipid metabolism regulators reveals molecular clusters and immunological characterization in polycystic ovarian syndrome

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