Atherogenic dyslipidemia and diabetes mellitus: what&amp;rsquo;s new in the management arena?

Kumar, Ajoy

doi:10.2147/vhrm.s5686

Cited by 36 publications

(31 citation statements)

References 28 publications

(28 reference statements)

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“…Additionally, NAC was reported to exert hypolipidemic effect in experimental mice (Korou et al, 2010). Suppression of serum lipoproteins and leptin is not only a result of the hepatoprotective potential of test agents but also a hepatoprotective mechanism as well, as dyslipidemia increases atherogenic risk (Kumar & Singh, 2010), while leptin enhances oxidative and nitrosative stress and also stimulates Kupffer cells (Chatterjee et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Ali

Messiha

Abdellatif

2015

Pharmaceutical Biology

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(2016) Protective effect of ursodeoxycholic acid, resveratrol, and Nacetylcysteine on nonalcoholic fatty liver disease in rats, Pharmaceutical Biology, 54:7, 1198-1208, DOI: 10.3109/13880209.2015 -a), glucose, albumin, renal functions (urea, creatinine), lipid profile (total cholesterol; TC, triglycerides, high density lipoproteins, low density lipoproteins; LDL-C, very low density lipoproteins, leptin), and oxidative stress markers (hepatic malondialdehyde; MDA, glutathione; GSH, glutathione-S-transferase; GST) were measured using automatic analyzer, colorimetric kits, and ELISA kits, supported by a liver histopathological study.Results: RSV and NAC administration significantly improved liver index (RSV only), alanine transaminase (52, 52%), TNF-a (70, 70%), glucose (69, 80%), albumin (122, 114%), MDA (55, 63%), GSH (160, 152%), GST (84, 84%), TC (86, 86%), LDL-C (83, 81%), and leptin (59, 70%) levels compared with steatosis control values. A combination of RSV or NAC with UDCA seems to ameliorate their effects. Discussion and conclusion: RSV and NAC are effective on NAFLD through antioxidant, antiinflammatory, and lipid-lowering potentials, where as RSV seems better than UDCA or NAC.

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Section: Discussionmentioning

confidence: 99%

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Ali

Messiha

Abdellatif

2015

Pharmaceutical Biology

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“…Moreover, the results presented by Ferroni et al are consistent with current treatment recommendations. In fact, in patients with atherogenic dyslipidemia and T2D, lifestyle modifications and statin therapy are recommended regardless of baseline LDL for those with overt CVD [20]. At times, for individuals in primary prevention aged >40 years with one or more CVD risk factors the use not only of statin therapy but also of aspirin, both involved in the reduction of different prothrombothic pathways, is a topic of debate.…”

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confidence: 99%

Beyond Hyperglycemia in Diabetes: Role of Statin Treatment on Thrombogenesis Triggered by Inflammation

Perego

Davı̀

2012

Cardiovasc Drugs Ther

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Type 2 diabetes mellitus (T2D) constitutes a growing global public health problem and its prevalence is estimated to increase during the next decades, especially in the developing countries. To date, 15 % of the whole population is considered at high risk to develop T2D [1]. T2D is associated with a decrease of health-related quality of life and overall life expectancy, mainly due to an increased risk for cardiovascular disorders. Indeed, T2D is commonly associated with both microvascular and macrovascular complications [2]. Macrovascular complications manifest themselves as accelerated atherosclerosis, clinically resulting in premature coronary artery disease, increased risk of cerebrovascular disease, and severe peripheral vascular disease [2]. Patients with T2D have a a two-to four-fold increase in the risk of coronary artery disease (CAD) and patients with DM but without previous myocardial infarction (MI) carry the same level of risk for subsequent acute coronary events as non-diabetic patients with previous MI [3,4] so that T2D has been defined a CAD equivalent.T2D is associated with a prothrombotic state characterized by a number of changes in thrombotic and fibrinolytic coagulation factor level/activity, which together increase the risk of thrombus formation. Both glucose and insulin seem to play a role in the pathogenesis of this prothrombotic state [5]. In vitro induced thrombin generation is increased in platelet-rich plasma from diabetics compared with that from healthy subjects and a significant elevation of thrombin levels can be demonstrated in T2D patients in poor metabolic control when compared with well controlled patients [6]. Moreover, a significant correlation can be observed between improved glycemic control and blood thrombogenicity, as reflected by a reduction in ex-vivo thrombus formation in a Badimon perfusion chamber [7]. Improved glycemic control is the only significant predictor of a decrease in blood thrombogenicity, irrespective of treatment allocation [7]. Enhanced levels of prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complexes (TAT) have been shown in T2D patients in comparison with healthy subjects [8].A hypercoagulable state, detected by thrombin generation tests, was reported in patients with T2D, explaining, at least partially, the high incidence of vascular events in these patients [9].Platelets of patients with DM are characterized by dysregulation of several signaling pathways, leading to an hyperreactive phenotype with enhanced adhesion, aggregation, and activation [10]. Chronic hyperglycemia has been clearly identified as a causal factor for in vivo platelet activation [11]. Our group firstly demonstrated enhanced thromboxane (TX) biosynthesis in T2D, providing evidence for its platelet origin. Moreover, tight metabolic control led to reduction of TX metabolite urinary levels [11]. Interestingly, inflammatory mediators (such as CD40L) derived from platelets expand the functional repertoire of platelets from players of hemostasis and thrombosis to powerful a...

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“…Several studies have documented the association between diabetes mellitus and abnormalities in lipid metabolism [33]. Dyslipidemia is believed to be a major risk factor for development of various diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Propolis restored adiponectin level in type 2 diabetes through PPARγ activation

Elissa

Elsherbiny²,

Magmomah³

2015

Egyptian Journal of Basic and Applied Sciences

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Available online A B S T R A C TAdipose tissue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin. Hypoadiponectinemia contributes to the development of obesity and related disorders such as diabetes, hyperlipidemia, and cardiovascular diseases. In this study, we investigated the effects of Brazilian propolis on adiponectin levels in type 2 diabetes mellitus (T2DM), the mechanism of signaling pathway was explored as well. T2DM was induced in male Wistar rats using high fat diet and low dose of streptozotocin (STZ, 35 mg/kg, i.p.).Propolis was administered by oral tubes. Peroxisome proliferator activated receptor gamma (PPARγ) levels in sub abdominal adipose tissue, serum levels of adiponectin, tumor necrosis factor-α (TNF-α) and insulin were detected by Enzyme Linked Immunosorbent Assay (ELISA).Malondialdehyde (MDA) and reduced glutathione (GSH) in sub abdominal adipose tissue, fasting plasma glucose, plasma triglycerides and total cholesterol levels were measured by colorimetric method. Results showed that Brazilian propolis ameliorated hypoadiponectinemia in T2DM rats and relieved high glucose-induced adiponectin decrease. The signaling pathway analysis indicated that PPARγ regulation was involved. In conclusion, Brazilian propolis could have beneficial effect in T2DM by increasing tissue PPARγ levels, restoring serum adiponectin levels, enhancing insulin sensitivity and subsequently, attenuating elevated glucose level.

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Atherogenic dyslipidemia and diabetes mellitus: what’s new in the management arena?

Cited by 36 publications

References 28 publications

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Protective effect of ursodeoxycholic acid, resveratrol, andN-acetylcysteine on nonalcoholic fatty liver disease in rats

Beyond Hyperglycemia in Diabetes: Role of Statin Treatment on Thrombogenesis Triggered by Inflammation

Propolis restored adiponectin level in type 2 diabetes through PPARγ activation

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