Atherogenic changes of low-density lipoprotein susceptibility to oxidation, and antioxidant enzymes in pulmonary tuberculosis

Nezami, Nariman; Ghorbanihaghjo, Amir; Rashtchizadeh, Nadereh; Argani, Hassan; Tafrishinejad, Arash; Ghorashi, Sona; Hajhosseini, Babak

doi:10.1016/j.atherosclerosis.2011.03.025

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…In particular, C. pneumoniae and M. tuberculosis have been implicated in atherosclerosis in several epidemiologic and clinical studies 28 , 29 . These bacteria were also reported to induce LDL oxidation 4 , 30 . In the present study, LDL oxidation induced by HSP60 and Pep19 from Pg was significantly stronger than that induced by identical peptides from C. pneumoniae or M. tuberculosis .…”

Section: Discussionsupporting

confidence: 52%

“…28,29 These bacteria were also reported to induce LDL oxidation. 4,30 In the present study, LDL oxidation induced by HSP60 and Pep19 from Pg was significantly stronger than that induced by identical peptides from C. pneumoniae or M. tuberculosis. Within the context of the present results and according to another study, antigenicity of Pep19 from Pg HSP60 may be considered higher than that of C. pneumoniae and M. tuberculosis.…”

Section: Figurementioning

confidence: 37%

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Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low‐Density Lipoprotein Oxidation

Joo

Sun

Chung

et al. 2017

Journal of Periodontology

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Section: Discussionsupporting

confidence: 52%

Section: Figurementioning

confidence: 37%

Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low‐Density Lipoprotein Oxidation

Joo

Sun

Chung

et al. 2017

Journal of Periodontology

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“…However, foamy macrophage formation is a straightforward biological process and we used this simplified model for comparison to previous studies. These macrophage phenotypes are consistent with previous reports of in vitro foamy macrophage formation [ 20 , 31 ]. Most importantly, TLP treated macrophages had extensive lipid body accumulation per cell compared to macrophages treated with other LDLs (Fig.…”

Section: Resultssupporting

confidence: 93%

Exploring the value of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children

et al. 2022

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Background Current TB diagnostic methods available have been developed for adults and development efforts have neglected the differences in disease and sampling that occur between adults and children. Diagnostic challenges are even greater in HIV co-infected children and infants. Methods and results We established a sandwich ELISA assay to detect Mycobacterium tuberculosis modified lipoprotein (TLP) ex vivo in plasma. The study population contains plasma samples from 21 patients with active TB and 24 control samples with no TB, collected in the International Maternal Pediatric Adolescent AIDS Clinical Trails (IMPAACT) P1041 study. Retrospective analysis was performed and the results demonstrate that the median plasma levels of TLP in control subjects are 2.7 fold higher than the median plasma values in active TB subjects (p < 0.001). Conclusions Plasma levels of TLP are elevated with active TB disease in HIV positive subjects and deserves further exploration as an indicator for TB detection in children.

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“…In contrast, MDA-LDL, commonly associated with atherosclerosis, treated macrophages exhibited more extensive accumulation of lipid bodies than the LDL treated macrophages. These macrophage phenotypes are consistent with previous reports of in vitro foamy macrophage formation (20, 29). Most importantly, TLP treated macrophages had extensive lipid body accumulation per cell compared to macrophages treated with other LDLs (Figure 2 and S1B).…”

Section: Resultssupporting

confidence: 93%

Retrospective feasibility study of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children

Yang

Wipperman

Nachman

et al. 2021

Preprint

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Background: Current TB diagnostic methods available have been developed for adults and development efforts have neglected the differences in disease and sampling that occur between adults and children. Diagnostic challenges are even greater in HIV co-infected children and infants. Methods and results: We established a sandwich ELISA assay to detect Mycobacterium tuberculosismodified lipoprotein (TLP) ex vivo in plasma. The study population contains plasma samples from 21 patients with active TB and 24 control samples with no TB, collected in the International Maternal Pediatric Adolescent AIDS Clinical Trails (IMPAACT) P1041 study. Retrospective analysis was performed and the result demonstrate that TLP level is associated with TB disease. Conclusions: Plasma levels of TLP associate with active TB disease in HIV positive subjects and can be used as an indicator for TB detection in children.

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Atherogenic changes of low-density lipoprotein susceptibility to oxidation, and antioxidant enzymes in pulmonary tuberculosis

Cited by 9 publications

References 24 publications

Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low‐Density Lipoprotein Oxidation

Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low‐Density Lipoprotein Oxidation

Exploring the value of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children

Retrospective feasibility study of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children

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