Atherogenic and Haematologic Indices of Paracetamol- Overdosed Albino Rats Treated With Aqueous Leaf Extracts of Euphorbia Heterophylla and Jatropha Curcas

Abstract

Objective: The protective effect of aqueous leaf extracts of Euphorbia heterophylla and Jatropha curcas against paracetamol-induced acute changes in lipid, atherogenic and haematologic parameters of albino rats were studied.Methodology: Twenty-five adult male albino rats weighing 180 to 200 g were randomly assigned into 5 experimental groups (I-V) of five animals each. Group I animals were administered 10 ml of distilled water, while group II rats were given 1000 mg/kg paracetamol. Groups III-V were pretreated with vitamin C (500 mg/kg), E. heterophylla (200 mg/kg) and J. curcas (1000 mg/kg) respectively, 1 h before administration of 1000 mg/kg paracetamol. The animals were orally administered the extracts/drugs daily for 14 days.Result: Paracetamol administration reduced significantly (p<0.05) the total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and total non HDL-c concentrations as well as white blood cell (WBC) count of the animals when compared with the control. Pre-treatment of the animals with vitamin C non-significantly (p>0.05) countered the observed effects of paracetamol overdose more than the extracts of E. heterophylla and J. curcas. Acute paracetamol overdose did not significantly (p>0.05) affect most of the atherogenic risk predictor indices and haematological parameters studied. Conclusion:The results indicate that atherogenic and haematologic indices were less responsive than lipid parameters to paracetamol-induced toxicity. Furthermore, aqueous leaf extracts of E. heterophylla and J. curcas had less protective effect than vitamin C against serum lipidaemic changes induced by paracetamol.

Ameliorative Potentials of Persea americana Mill (Avocado) Seed Extract on Acetaminophen-induced Hepatic Insufficiency in Rats

“…The activities of the antioxidant enzymes; Superoxide dismutase (SOD) and Catalase and the serum lipid levels of total cholesterol and triacylglycerol (TAG) were also monitored in all the animal groups (Table 3). In tissue damage resulting from acetaminophen toxicity, these serum parameters are usually decreased [42,43,44].…”

“…The liver is central to lipid metabolism especially cholesterol and lipoproteins and also involved in regeneration of reduced glutathione (GSH) required to regulate lipid peroxidation processes [42]. Thus, the observed significant decrease in the activities of these enzymes and lipid levels may have resulted from induction of hepatic damage by acetaminophen.…”