We present X-ray source catalogs for the ≈7 Ms exposure of the Chandra Deep Field-South (CDF-S), which covers a total area of 484.2arcmin 2 . Utilizing WAVDETECT for initial source detection and ACIS Extract for photometric extraction and significance assessment, we create a main source catalog containing 1008 sources that are detected in up to three X-ray bands: 0.5-7.0keV, 0.5-2.0keV, and 2-7keV. A supplementary source catalog is also provided,including 47 lower-significance sources that have bright ( K 23 s ) near-infrared counterparts. We identify multiwavelength counterparts for 992 (98.4%) of the main-catalog sources, and we collect redshifts for 986 of these sources, including 653 spectroscopic redshifts and 333 photometric redshifts. Based on the X-ray and multiwavelength properties, we identify 711 active galactic nuclei (AGNs) from the main-catalog sources. Compared to the previous ≈4 Ms CDF-S catalogs, 291 of the main-catalog sources are new detections. We have achieved unprecedented X-ray sensitivity with average flux limits over the central ≈1 arcmin 2 region of ≈1.9×10 −17 , 6.4×10 −18 , and 2.7×10 −17 ergcm −2 s −1 in the three X-ray bands, respectively. We provide cumulative number-count measurements observing, for the first time, that normal galaxies start to dominate the X-ray source population at the faintest 0.5-2.0keV flux levels. The highest X-ray source density reaches ≈50,500 deg −2 , and 47%±4% of these sources are AGNs (≈23,900 deg −2 ).