ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression

Su, Bao-Chang; Xiao, Kang-Ming; Wang, Kang-long; Yang, Sheng-Fu; Huang, Zhang-Xiong; Luo, Ji-Wen

doi:10.1007/s12032-023-02148-w

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…PNPLA2 mRNA expression is a compensatory mechanism to deal with larger LD preferentially, while autophagy targets small LDs [ 11 , 140 ] and is positively correlated with serum leptin levels [ 11 ]. Autophagy of LD by PNPLA2 is also a possible mediator of tissue damage [ 141 , 142 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans

De la Cruz-Color,

Dominguez-Rosales,

Maldonado-González

et al. 2024

IJMS

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Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin resistance is not fully understood, and its contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This study evaluated the contribution of the leptin axis to MASLD in humans. Forty-three participants, mostly female (86.04%), who underwent cholecystectomy were biopsied. Of the participants, 24 were healthy controls, 8 had MASLD, and 11 had metabolic dysfunction-associated steatohepatitis (MASH). Clinical and biochemical data and the gene expression of leptin, leptin receptor (LEPR), suppressor of cytokine signaling 3 (SOCS3), sterol regulatory element-binding transcription factor 1 (SREBF1), stearoyl-CoA desaturase-1 (SCD1), and patatin-like phospholipase domain-containing protein 2 (PNPLA2), were determined from liver and adipose tissue. Higher serum leptin and LEPR levels in the omental adipose tissue (OAT) and liver with MASH were found. In the liver, LEPR was positively correlated with leptin expression in adipose tissue, and SOCS3 was correlated with SREBF1-SCD1. In OAT, SOCS3 was correlated with insulin resistance and transaminase enzymes (p < 0.05 for all. In conclusion, we evidenced the correlation between the peripheral leptin resistance axis in OAT–liver crosstalk and the complications of MASLD in humans.

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Section: Discussionmentioning

confidence: 99%

Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans

De la Cruz-Color,

Dominguez-Rosales,

Maldonado-González

et al. 2024

IJMS

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Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights

Soleimani,

Saeedi,

Al-Asady

et al. 2024

CPD

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Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.

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ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression

Cited by 2 publications

References 21 publications

Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans

Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans

Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights

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