ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients

Lakatos, Péter L.; Szamosi, Tamás; Szilvási, Anikó; Molnar, Edit; Lakatos, László; Kovács, Ágota; Molnár, Tamás; Altorjay, István; Papp, Mária; Tulassay, Zsolt; Miheller, Pál; Papp, J.; Tordai, Attila; Andrikovics, Hajnalka

doi:10.1016/j.dld.2008.03.022

Cited by 51 publications

(42 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in a very recent study McCarroll et al 56 have shown that the causal variant responsible for IRGM Figure 1 Pooled data for the ATG16L1 rs2241880 susceptibility allele frequency (SAF). (a) Pooled data of Australian, 39 Belgian, 16 British, 14,21,23,25 Canadian, 31 Dutch, 28 German, 14,29,30 Italian, 27,33 Hungarian, 34 Japanese, 22 New Zealander, 26 North American 15,24 and Spanish cohorts for Crohn's disease (CD). (b) Pooled data of Australian, 39 British, 21,23,37 Canadian, 31 Dutch, 28 German, 14,29,30 Italian, 33 Hungarian, 34 New Zealander, 26,39 North American 15 and Spanish cohorts for ulcerative colitis (UC).…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16][21][22][23][24][25][26][27][28][29][30][31][32][33][34]38,39 Funnel plots and Egger tests were performed to analyse the publication bias of the meta-analysis. No statistically significant values were observed in CD studies (P ¼ 0.6) or UC studies (P ¼ 0.4), with symmetric funnel plots for both studies (Supplementary Figure 1).…”

Section: Association Of Atg16l1 and Irgm With Ibd Rj Palomino-moralesmentioning

confidence: 99%

“…[14][15][16] A large number of subsequent association studies have replicated the strong association of this gene with CD. [21][22][23][24][25][26][27][28][29][30][31][32][33][34] IRGM (immunity-related guanosine triphosphatase, the human homologue of mouse Irgm/Lrg47) encodes a GTP-binding protein that induces autophagy and plays an important role in innate immunity against intracellular pathogens. 35,36 Association of two immediately flanking IRGM gene polymorphisms (rs13361189 and rs4958847) with CD has recently been reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

et al. 2009

View full text Add to dashboard Cite

The aim of this study was to determine the role of the ATG16L1 (rs2241880) and IRGM (rs13361189 and rs4958847) genes polymorphism in Crohn's disease (CD) and ulcerative colitis (UC). Our study included 557 CD and 425 UC patients and 672 ethnically matched Spanish controls and a meta-analysis with the data published to date. The polymorphisms were genotyped using predesigned TaqMan single nucleotide polymorphism genotyping assays. There was a statistically significant difference in the distribution of the ATG16L1 rs2241880 G allele between CD patients and controls in the Spanish population: P ¼ 6.5 Â 10 À9 , odds ratio (OR) ¼ 1.62. Although no differences were observed between UC patients and controls in the Spanish cohort, a meta-analysis demonstrated that the ATG16L1 G allele increase significantly risk for UC (P ¼ 0.0003, pooled OR ¼ 1.08). In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P ¼ 1.07 Â 10 À19 , pooled OR ¼ 1.34; rs4958847 A allele P ¼ 2.78 Â 10 À17 , pooled OR ¼ 1.31) and UC (rs13361189 P ¼ 0.0069, pooled OR ¼ 1.16; rs4958847 P ¼ 0.014, pooled OR ¼ 1.13). In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Association Of Atg16l1 and Irgm With Ibd Rj Palomino-moralesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Multiple splice variants have been reported; however, no significant difference in expression was observed in CD vs control tissues. Expression of ATG16L1 was independent of the rs2241880 genotype (Lakatos et al 2008). …”

Section: Gene-gene Interactions Among the Il23/il17 Genesmentioning

confidence: 93%

“…Duerr et al (2006) reported on an association between Crohn's Disease (CD, a chronic inflammatory disease of gastrointestinal tract) and variants in the IL-23R gene (Duerr et al 2006;Lakatos et al 2008). A study by Yu et al (2012) showed that the IL-23R rs7530511 and rs11805303 variants were associated with UC susceptibility in a Chinese Han population.…”

Section: Genetic Variability In the Il23r Genementioning

confidence: 99%

Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

Abdollahi

Tavasolian

Momtazi‐Borojeni

et al. 2016

Journal of Immunotoxicology

View full text Add to dashboard Cite

Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: A Study in the Spanish population and a meta-analysis

Márquez

Núñez

Martínez

et al. 2009

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

show abstract

ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients

Cited by 51 publications

References 26 publications

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: A Study in the Spanish population and a meta-analysis

Contact Info

Product

Resources

About