2024
DOI: 10.1080/15548627.2024.2361580
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ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1

Miao-Qing Zhang,
Jian-Rui Li,
Lu Yang
et al.

Abstract: ATG10S is a newly discovered subtype of the autophagy protein ATG10. It promotes complete macroautophagy/autophagy, degrades multiple viral proteins, and increases the expression of type III interferons. Here, we aimed to investigate the mechanism of ATG10S cooperation with IFNL1 to degrade viral proteins from different viruses. Using western blot, immunoprecipitation (IP), tandem sensor RFP-GFP-LC3B and in situ proximity ligation assays, we showed that exogenous recombinant ATG10S protein (rHsATG10S) could en… Show more

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