2007
DOI: 10.1111/j.1600-0749.2007.00414.x
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ATF2 on the double – activating transcription factor and DNA damage response protein

Abstract: SummarySignal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, thro… Show more

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Cited by 89 publications
(82 citation statements)
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References 91 publications
(100 reference statements)
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“…ATF2 has multiple roles in a cell; in the nucleus it can impact transcription (via heterodimerization with c-Fos or c-Jun) and be involved in chromatin remodeling and DNA repair; in the cytoplasm ATF2 interacts with voltage-dependent ion channels, affecting mitochondria permeability. 24,25 Other studies have highlighted JNK-mediated DNA damage, phosphorylation of Bcl-2 and Bim, or increased expression of Bax, Bak, Puma or Noxa in response to long exposures (24 h) of microtubule disrupting agents in solid tumors. [26][27][28] However, with the exception of increased Noxa, we did not observe these other biomarkers in leukemia (data not shown), and acute Noxa induction does not appear to rely solely on JNK signaling.…”
Section: Discussionmentioning
confidence: 99%
“…ATF2 has multiple roles in a cell; in the nucleus it can impact transcription (via heterodimerization with c-Fos or c-Jun) and be involved in chromatin remodeling and DNA repair; in the cytoplasm ATF2 interacts with voltage-dependent ion channels, affecting mitochondria permeability. 24,25 Other studies have highlighted JNK-mediated DNA damage, phosphorylation of Bcl-2 and Bim, or increased expression of Bax, Bak, Puma or Noxa in response to long exposures (24 h) of microtubule disrupting agents in solid tumors. [26][27][28] However, with the exception of increased Noxa, we did not observe these other biomarkers in leukemia (data not shown), and acute Noxa induction does not appear to rely solely on JNK signaling.…”
Section: Discussionmentioning
confidence: 99%
“…However, the most surprising conclusion from the knockout mouse work is that ASCIZ has a major function in vivo as a crucial, likely transcriptional, regulator of embryonic development, particularly of the respiratory system. In this sense, ASCIZ joins a growing list of proteins such as Sp1, 13,14 PTIP 15 and ATF 16 with important developmental roles as transcriptional regulators that are separate from their scaffold functions as ATM substrates in the DNA damage response. A better understanding of the molecular mechanisms involved in the two diverse functions of ASCIZ using an expanded range of conditional deletions and by the generation of specific separation-of-function alleles, might thus also provide useful insights into the regulation of these other proteins with dual functions in transcription and the DNA damage response.…”
Section: Severe Organ Development Defects Including Complete Absence mentioning
confidence: 99%
“…Among others, genes targeted by amATF-2 regulate transcription factors and proteins engaged in stress and DNA damage response (Bhoumik et al 2007). (3) amDHAP-AT: Dihydroxy acetone phosphate acyl transferase is involved in lipid metabolism, facilitating the production of triacylglycerides (TAG).…”
Section: Introductionmentioning
confidence: 99%