Atenolol

Čaplar, Vesna; Mikotić-Mihun, Zvonimira; Hofman, Hrvoje; Kuftinec, Josip; Kajfež, F.; Nagl, A.; Blažević, Nikola

doi:10.1016/s0099-5428(08)60187-2

Cited by 12 publications

(3 citation statements)

References 18 publications

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“…Thus the material identities are still preserved. The observed decrease in relative intensity is due to partial dissociation of the materials induced by γ-irradiation [22]. This increased intensity due to the increased material degree of crystallinity, as caused by induced free radical recombination, or through polymerization mechanism of some lattice structure.…”

Section: Resultsmentioning

confidence: 95%

Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug

Wassel¹,

Alzamel²,

Alkhaldi³

et al. 2017

Asian J. Chem.

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Metoprolol active ingredient has been investigated using X-ray diffraction analysis, thermogravimetry, differential thermal analysis, infrared and high-pressure liquid chromatography before and after exposure to 5 up to 50 kGy absorbed dose. The results obtained indicated high stability of metoprolol toward γ-absorbed dose. The scheme of interaction of γ-rays with metoprolol has been considered.

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Section: Resultsmentioning

confidence: 95%

Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug

Wassel¹,

Alzamel²,

Alkhaldi³

et al. 2017

Asian J. Chem.

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“…Administration of conventional atenolol tablets has been reported to exhibit fluctuations in plasma drug levels, resulting in side effects such as hypopiesia, bradycardia, dizziness, and gastrointestinal (GI) upset. [10]…”

Section: Introductionmentioning

confidence: 99%

Development, evaluation, and influence of formulation and process variables on in vitro performance of oral elementary osmotic device of atenolol

Arjun

Dudhipala

Sunitha

et al. 2016

Int J Pharma Investig

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Purpose:Osmotic devices are the most promising strategy-based systems for controlled drug delivery. By optimizing formulation and processing parameters, possible to develop osmotic systems to deliver drugs at predetermined rate with high in vitro-in vivo correlation. The aim of the present investigation was to develop an oral elementary osmotic pump (EOP) of atenolol with zero-order or near zero-order drug release profile.Materials and Methods:Differential scanning calorimetry and Fourier transform-infrared spectroscopy studies did not show any evidence of interaction between the drug and excipients. Formulations were prepared by wet granulation method and coated with cellulose acetate (CA)/ethyl cellulose containing varying amounts of dibutyl phthalate (DBP)/poly (ethylene glycol)-400 as a plasticizer. The effect of different formulation variables on drug release: type and concentration of osmogen and plasticizer, size of the delivery orifice, nature of the rate controlling membrane, and membrane weight gain were studied. The release studies also compared with marketed immediate release formulation.Results:Formulations containing NaCl, mannitol, and combination of both as osmogens in the drug:osmogen ratio of 1:3 and 1:4 showed zero-order drug release. Marketed tablet releases more than 95% drug in different media in 90 min. The 4% CA in acetone with DBP as a plasticizer (at a concentration of 15% w/w of polymer), with orifice diameter 565 μm, and 8.05% increase in weight on coating were found to control the drug release independent of pH and agitational intensity. The formulations were stable for 3 months as per the International Council for Harmonisation guidelines.Conclusion:Atenolol containing EOPs and process parameters on release studies were studied and confirmed based on osmotic technology.

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“…Different analytical methods were developed for the determination of atenolol. A good guide for the work published on atenolol up to 1984 is presented as a comprehensive monograph in analytical profiles of drug substances [3]. The most recent articles concerning the analysis of this drug include spectroscopic methods [1,[4][5][6][7][8][9][10], chromatographic methods including GC [11][12][13] and HPLC [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Stability-indicating HPLC Method for the Determination of Atenolol in Pharmaceutical Preparations

Belal¹

2012

J Chromat Separation Techniq

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Atenolol, (2-[4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy] phenyl]acetamide [1] (Figure 1), is a cardioselective beta blocker and reported to lack intrinsic sympathomimetic activity and membranestabilizing properties. It is used in the management of hypertension, angina pectoris, cardiac arrhythmias, and myocardial infarction. It may also be used in the prophylactic treatment of migraine. The usual oral dose for hypertension or angina pectoris is 50-100 mg daily. Atenolol is co-formulated with chlorthalidone, hydrochlorothiazide, nifedipine, amiloride HCl, hydralazine HCl, indapamide, and bendrofluazide [2].

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Atenolol

Cited by 12 publications

References 18 publications

Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug

Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug

Development, evaluation, and influence of formulation and process variables on in vitro performance of oral elementary osmotic device of atenolol

Stability-indicating HPLC Method for the Determination of Atenolol in Pharmaceutical Preparations

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