Ataxic Hemiparesis Associated with Cortical Infarct Localized in the Postcentral Gyrus

Kinjo, Yoshino; Suda, Satoshi; Sakamoto, Yuki; Okubo, Seiji; Kimura, Kazumi

doi:10.2169/internalmedicine.8806-17

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Pontine infarction (PI) accounts for 7% of ischemic strokes and is the most common type of posterior circulation infarction (Wang et al, 2018). Typical clinical manifestations of PI include pure motor hemiplegia, ataxia, dysarthria, dysphagia, and cognitive impairment (Kinjo et al, 2017;Lapa et al, 2017;Li et al, 2020). Long-term follow-up has revealed that some patients with PI experience a poor prognosis with impaired motor or cognitive function (Mijajlovic et al, 2017;Payabvash et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Disrupted Regional Cerebral Blood Flow and Functional Connectivity in Pontine Infarction: A Longitudinal MRI Study

Wei

Wang

et al. 2020

Front. Aging Neurosci.

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Abnormal cerebral blood flow (CBF) and resting-state functional connectivity (rs-FC) are sensitive biomarkers of disease progression and prognosis. This study investigated neural underpinnings of motor and cognitive recovery by longitudinally studying the changes of CBF and FC in pontine infarction (PI). Twenty patients underwent three-dimensional pseudo-continuous arterial spin labeling (3D-pcASL), resting-state functional magnetic resonance imaging (rs-fMRI) scans, and behavioral assessments at 1 week, 1, 3, and 6 months after stroke. Twenty normal control (NC) subjects underwent the same examination once. First, we investigated CBF changes in the acute stage, and longitudinal changes from 1 week to 6 months after PI. Brain regions with longitudinal CBF changes were then used as seeds to investigate longitudinal FC alterations during the follow-up period. Compared with NC, patients in the left PI (LPI) and right PI (RPI) groups showed significant CBF alterations in the bilateral cerebellum and some supratentorial brain regions at the baseline stage. Longitudinal analysis revealed that altered CBF values in the right supramarginal (SMG_R) for the LPI group, while the RPI group showed significantly dynamic changes of CBF in the left calcarine sulcus (CAL_L), middle occipital gyrus (MOG_L), and right supplementary motor area (SMA_R). Using the SMG_R as the seed in the LPI group, FC changes were found in the MOG_L, middle temporal gyrus (MTG_L), and prefrontal lobe (IFG_L). Correlation analysis showed that longitudinal CBF changes in the SMG_R and FC values between the SMG_R and MOG_L were associated with motor and memory scores in the LPI group, and longitudinal CBF changes in the CAL_L and SMA_R were related to memory and motor recovery in the RPI group. These longitudinal CBF and accompany FC alterations may provide insights into the neural mechanism underlying functional recovery after PI, including that of motor and cognitive functions.

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