“…In general, it has been estimated that nonsense mutations account for ~11% of all variations that cause inherited disorders and as many as 20% of the protein-coding region located, single base-pair mutations that cause these diseases (Ryan 2014, HGMD 2015. PTCs can originate from nonsense mutations, frameshift mutations, or from aberrant splicing that generates mRNA isoforms that lead , Suwanmanee et al 2002, Scaffidi and Misteli 2005, van Deutekom et al 2007, Kinali et al 2009, Cirak et al 2011, Hua et al 2010, Nlend Nlend et al 2010, Taylor et al 1999, Giles et al 1999 Single-stranded oligonucleotides (ssODNs) (Jana and Deb 2006, Hainrichson et al 2008, Vecsler et al 2011, Peltz et al 2013.…”