ATAC-ing human tissue Treg cells

Köhne, Maren; Beyer, Marc

doi:10.1016/j.immuni.2021.03.014

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The function of Tregs depends on the regulation and manipulation of their gene expression. With few exceptions, the expression of forkhead P3 (Foxp3), CD25, CTLA4, HELIOS, and GITR defines the Treg lineage identity ( 4 ), although various subsets of Tregs display additional characteristics ( 5 ). The expression of Foxp3, the master regulator component of Treg transcription ( 6 , 7 ), is controlled in multiple ways, including epigenetic mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

Christensen

Hancock

2022

Front. Immunol.

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T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression. Many such complexes act mechanistically by altering epigenetic profiles of genes important to Treg function, including the forkhead P3 (Foxp3) transcription factor. Complexes that form with certain members of the histone/protein deacetylase (HDAC) class of enzymes, like HDACs 1, 2, and 3, along with histone methyltransferase complexes, are important in the induction and stabilization of Foxp3 and Treg identity. The functional behavior of both circulating and intratumoral Tregs greatly impacts the antitumor immune response and can be predictive of patient outcome. Thus, targeting these regulatory complexes within Tregs may have therapeutic potential, especially in personalized immunotherapies.

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Section: Introductionmentioning

confidence: 99%

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

Christensen

Hancock

2022

Front. Immunol.

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The potential of regulatory T cell-based therapies for alopecia areata

Wan

Xie

et al. 2023

Front. Immunol.

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Cytotoxic T lymphocyte has been a concern for the etiopathogenesis of alopecia areata (AA), some recent evidence suggests that the regulatory T (Treg) cell deficiency is also a contributing factor. In the lesional scalp of AA, Treg cells residing in the follicles are impaired, leading to dysregulated local immunity and hair follicle (HF) regeneration disorders. New strategies are emerging to modulate Treg cells’ number and function for autoimmune diseases. There is much interest to boost Treg cells in AA patients to suppress the abnormal autoimmunity of HF and stimulate hair regeneration. With few satisfactory therapeutic regimens available for AA, Treg cell-based therapies could be the way forward. Specifically, CAR-Treg cells and novel formulations of low-dose IL-2 are the alternatives.

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ATAC-ing human tissue Treg cells

Cited by 2 publications

References 10 publications

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

The potential of regulatory T cell-based therapies for alopecia areata

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