Today's global society creates an environment characterised by complex problems, solutions to which require transcendence of traditional discipline-based boundaries, and new forms of knowledge-sharing. Higher education (HE) has a central role in interdisciplinary knowledge creation and dissemination, reinforced by funding councils, professional bodies and government policy. That notwithstanding, there is currently no recognised best-practice approach to interdisciplinary working in UK HE institutes. The aim of this paper is to develop a best-practice model to facilitate interdisciplinarity within the UK HE sector, focusing on teaching and learning (T&L) and the student learning experience. Based on the results of an exploratory and empirical enquiry a HE Interdisciplinary Model of best-practice (HIM) is proposed. HIM is informed by the development of four themes and six ensuing enablers from a synthesis of perceived barriers, possible facilitators and potential solutions to interdisciplinarity within UK HE. However, further research is necessary to validate the proposed model.