AT oligonucleotides inducing B lymphocyte activation exist in probiotic Lactobacillus gasseri

Kitazawa, Haruki; Ueha, Satoshi; Itoh, Shihoko; Watanabe, Hiroshi; Konno, Kei; Kawai, Yasushi; Saito, Tadao; Itoh, Takatoshi; Yamaguchi, Takahiro

doi:10.1016/s0168-1605(00)00500-6

Cited by 45 publications

(57 citation statements)

References 34 publications

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“…The number of lymphocytes was maximum on day 6 and 9 days post immunization. Observations of Kitazawa et al, (2001) that plant extracts enhanced multiplication of B lymphocytes by stimulating the expression of CD molecules (Cluster of Differentiation system), could be a possible mechanism for the enhancement observed in the present study. …”

Section: Total Lymphocytessupporting

confidence: 56%

“…The minimum count 14.5±0.310 6 cells/mm3 was found in 250 ppm leaf extract. The increase in WBC count observed in the present study might be due to the direct stimulatory effect of Peanut plant extracts on B cells and T cells or indirectly stimulating interleukins, and monokines secretions (Cross et al, 2002, Kitazawa et al, 2001. Chukwudi et al, 2011 observed that WBC counts in rats administered with Mucuna pruriens increased significantly in comparison to control.…”

Section: Total Wbcmentioning

confidence: 44%

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Effect of Peanut (Arachis hypogea L.) extracts as a feed additive on growth and hematological parameters of rohu fish (Labeo rohita) fingerlings

Mythily.¹,

Revathi²

2017

Int. J. Adv. Multidiscip. Res.

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The main objective of the present study is to improve the immune power of Labeo rohita by using Arachis hypogea plant leaf, seed and root extracts as immunostimulants. The specific antibody response, immunological and host resistance test were conducted on the medicated fish infected with Aeromonas hydrophila pathogen. The results obtained from the hematological studies show that the RBC count, total WBC count, and lymphocyte content were increased in the infected fish at higher concentration of all three extract. The feeds with seed extract of Arachis hypogea were able to stimulate the specific antibody response by increasing the titre value of antibody. It was observed that fish have survival percentage significantly at higher concentration (1000 ppm) of Arachis hypogea, when compared with the control. This research work suggests that the Arachis hypogea has immunostimulant activity by stimulating both specific and non-specific immunity at higher concentrations.

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Section: Total Lymphocytessupporting

confidence: 56%

Section: Total Wbcmentioning

confidence: 44%

Effect of Peanut (Arachis hypogea L.) extracts as a feed additive on growth and hematological parameters of rohu fish (Labeo rohita) fingerlings

Mythily.¹,

Revathi²

2017

Int. J. Adv. Multidiscip. Res.

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“…48,113,177 Note that ISS-DNA sequences have been identifi ed in a variety of probiotic strains, including LGG, 182 Lactobacillus delbrueckii ssp. bulgaricus NIAI B6, 183 Lactobacillus gasseri OLL2716, 184 and B. longum BB536. 185 The ISS-ODN from B. longum BB536 and LGG exhibited immunomodulatory activity in OVA-immunized mice after oral and i.p.…”

Section: Identifi Cation Of Active Probiotics Components and Receptormentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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“…In strain G50, cell wall components, which constitute heat-killed cells, may be a factor for immune modulation by this strain. It has been reported that CpG 24 and AT motifs 21 in bacterial DNA are responsible for enhancement of the immune system via Toll-like receptor 9 present on immunocompetent cells 42 . CpG and AT motifs in lactococci have not been studied yet.…”

Section: Immune Modulationmentioning

confidence: 99%

Lactococcus sp. as Potential Probiotic Lactic Acid Bacteria

Kimoto‐Nira

Mizumachi

Nomura

et al. 2007

JARQ

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The most widely used probiotic bacteria are lactobacilli and bifidobacteria, which have been isolated from the human gastrointestinal tract. The development of new probiotic strains, which are more feasible and beneficial organisms, is awaited in the dairy industry. Lactococci would be promising species because of their extensive usage in manufacturing dairy products such as cheese and fermented milk. However, there have been few studies on the probiotic activity of lactococci since they are traditionally not considered to be natural inhabitants of the human gastrointestinal tract. Recently, several works showed the possibility of the presence of lactococci in the flora of the human or animal gastrointestinal tract. In this review, we would like to propose Lactococcus sp. as new probiotic bacteria.

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AT oligonucleotides inducing B lymphocyte activation exist in probiotic Lactobacillus gasseri

Cited by 45 publications

References 34 publications

Effect of Peanut (Arachis hypogea L.) extracts as a feed additive on growth and hematological parameters of rohu fish (Labeo rohita) fingerlings

Effect of Peanut (Arachis hypogea L.) extracts as a feed additive on growth and hematological parameters of rohu fish (Labeo rohita) fingerlings

Probiotics and immunity

Lactococcus sp. as Potential Probiotic Lactic Acid Bacteria

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