At-a-glance - Trends in emergency department visits for acetaminophen-related poisonings: 2011–2019

Kaur, Jaskiran; McFaull, Steven R.; Bang, Felix

doi:10.24095/hpcdp.40.4.05

Cited by 7 publications

(10 citation statements)

References 11 publications

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“…Of these, female patients were more associated with acetaminophen poisonings along the entire period of study. This scenario has also been reported in the work of Kaur et al [18].…”

Section: Acetaminophen Poisoning Ratessupporting

confidence: 85%

Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end

Sanhueza-Aroca¹,

Verdugo-Silva²,

Olate-Fica³

et al. 2021

Nepal J Epidemiology

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Background: Acetaminophen (Paracetamol) is one of the most used and prescribed anti-inflammatory and analgesic drugs worldwide. It has become one of the main drugs related to accidental and intentional overdoses in many countries, including Chile. The objective of this work was to characterize acetaminophen poisonings occurred in Chile between the years 2001 and 2020. Methods: A retrospective study of acetaminophen poisonings among patients who were hospitalized in Chilean public and private hospitals was carried out between the years 2001 and 2020. Data was obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients who were admitted into either public or private healthcare settings with diagnosis of acetaminophen poisoning according to the WHO ICD-10. Statistical analyses were run to establish associations between variables selected in the study. Results: A total of 2,929 cases were included in the study. 77 % of the cases corresponded to female patients (p<0.05). Patients’ age range went from 0 to 81 years old. Adolescents and young adults resulted more involved in reported cases during the 2001-2020 period (p<0.001). During the first period of the study, accidental poisonings were more commonly reported, however in the recent years intentional cases increased their occurrence, especially among female patients (p<0.05). A multivariate logistic regression model considered as statistically significant (p<0.05) the interaction between the variables age, gender and year of the event. Conclusion: The present study identified a large number of acetaminophen poisonings reported in Chile during the 2001-2020 period. Cases were characterized including patients’ gender, age, and poisoning intent. Health authorities should consider these findings as an opportunity to improve public health associated with the use and misuse of over-the-counter drugs, including acetaminophen

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“…Of these, female patients were more associated with acetaminophen poisonings along the entire period of study. This scenario has also been reported in the work of Kaur et al [18].…”

Section: Acetaminophen Poisoning Ratessupporting

confidence: 85%

Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end

Sanhueza-Aroca¹,

Verdugo-Silva²,

Olate-Fica³

et al. 2021

Nepal J Epidemiology

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“…Almost all RCTs and meta-analyses reported numbers of adverse events from paracetamol that were inferior to those of NSAIDs and comparable to those of placebo. However, reviews on long-term observational data reported increased cardiovascular, gastrointestinal, and renal adverse events during therapy with paracetamol, especially in the high dose range; cases of acute liver failure have been reported after accidental and unintentional overdose of paracetamol [ 10 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ]. Acute liver failure is infrequent with an approximate incidence for all causes of 1/million/year and is declining [ 134 ].…”

Section: Safety and Toxicitymentioning

confidence: 99%

“…However, reviews on long-term observational data reported increased cardiovascular, gastrointestinal, and renal adverse events during therapy with paracetamol, especially in the high dose range; cases of acute liver failure have been reported after accidental and unintentional overdose of paracetamol [ 10 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ]. Acute liver failure is infrequent with an approximate incidence for all causes of 1/million/year and is declining [ 134 ]. In recent Canadian reports, the numbers of paracetamol ingestions reporting to the Emergency Department declined from April 2011 to February 2019 [ 134 ].…”

Section: Safety and Toxicitymentioning

confidence: 99%

“…Acute liver failure is infrequent with an approximate incidence for all causes of 1/million/year and is declining [ 134 ]. In recent Canadian reports, the numbers of paracetamol ingestions reporting to the Emergency Department declined from April 2011 to February 2019 [ 134 ]. Despite its rarity, acute liver failure generates interest and study by multiple disciplines because it affects all organ systems and requires substantial resource use [ 134 ].…”

Section: Safety and Toxicitymentioning

confidence: 99%

“…In recent Canadian reports, the numbers of paracetamol ingestions reporting to the Emergency Department declined from April 2011 to February 2019 [ 134 ]. Despite its rarity, acute liver failure generates interest and study by multiple disciplines because it affects all organ systems and requires substantial resource use [ 134 ]. Thusius et al reported that the vast majority of patients survived and recovered without lasting medical sequelae.…”

Section: Safety and Toxicitymentioning

confidence: 99%

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Paracetamol: A Review of Guideline Recommendations

Freo

Ruocco

Valerio

et al. 2021

JCM

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Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and pain-related disability, which are expected to rise with the rapid global population aging. Current medical treatments provide only partial relief. Furthermore, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are effective in young and otherwise healthy individuals but are often contraindicated in elderly and frail patients. As a result of its favorable safety and tolerability record, paracetamol has long been the most common drug for treating pain. Strikingly, recent reports questioned its therapeutic value and safety. This review aims to present guideline recommendations. Paracetamol has been assessed in different conditions and demonstrated therapeutic efficacy on both acute and chronic pain. It is active as a single agent and is additive or synergistic with NSAIDs and opioids, improving their efficacy and safety. However, a lack of significant efficacy and hepatic toxicity have also been reported. Fast dissolving formulations of paracetamol provide superior and more extended pain relief that is similar to intravenous paracetamol. A dose reduction is recommended in patients with liver disease or malnourished. Genotyping may improve efficacy and safety. Within the current trend toward the minimization of opioid analgesia, it is consistently included in multimodal, non-opioid, or opioid-sparing therapies. Paracetamol is being recommended by guidelines as a first or second-line drug for acute pain and chronic pain, especially for patients with limited therapeutic options and for the elderly.

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Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control?

Sansoucy

Naud

2023

Chem. Res. Toxicol.

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Drug toxicity is a major concern and has motivated numerous studies to elucidate specific adverse mechanisms, with acetaminophen being the favorite candidate in toxicology studies. Conversely, androgenic anabolic steroids (AASs) also represent a severe public health issue in sports for elite and non-elite athletes. Supraphysiological dosages of AASs are associated with various adverse effects, from cardiovascular to neurological repercussions including liver dysfunction. Yet, few studies have addressed the toxicity of anabolic steroids, and a significant amount of work will be needed to elucidate and understand steroid toxicity properly. This Perspective suggests ideas on how proteomics and liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-HRMS/MS) can contribute to (1) pinpoint serum proteins affected by substantial doses of anabolic steroids that would represent interesting novel candidates for routine testing and (2) provide additional knowledge on androgenic anabolic steroid toxicity to help raise awareness on the harmful effects. ■ CONTENTSIntroduction 1168 LC-MS/(MS)-

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At-a-glance - Trends in emergency department visits for acetaminophen-related poisonings: 2011–2019

Cited by 7 publications

References 11 publications

Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end

Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end

Paracetamol: A Review of Guideline Recommendations

Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control?

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