“…10,12,14 In clinical practice, because of these molecular effects, reduced weight gain, dysmenorrhea, bleeding, and acne or hirsutism are observed in response to CMA. 11,[14][15][16] CMA also has a reduced impact on metabolic markers (low-and high-density lipoprotein, insulin levels) in contrast to MPA. [11][12][13][14][15][16] Furthermore, CMA is the only progestin known to be safe and effective for women with high vascular risk, such as those with systemic lupus erythematosus and those with a history of venous thrombosis.…”