Asynchronous arterial systolic expansion as a marker of vascular aging

Yang, Woo In; Shim, Chi Young; Bang, Woo Dae; Oh, Chang‐Myung; Chang, Hyuk Jae; Chung, Namsik; Ha, Jong Won

doi:10.1097/hjh.0b013e32834c46dd

Cited by 17 publications

(14 citation statements)

References 25 publications

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“…This method also seems to be superior to other non-sonographic techniques evaluating arterial wall compliance. In an examination of the CCA by means of vector velocity imaging, the average peak circumferential strain and circumferential strain rate were negatively correlated with pulse-wave velocity (PVW) and with the augmentation index [ 11 ]. Although PVW is becoming the gold standard examination in the evaluation of arterial stiffness [ 6 ], it is pressure and heart rate dependant, requires special equipment, and in elderly subjects, with a more tortuous abdominal aorta, can be underestimated [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…As the reduced vessel wall compliance may be not just a surrogate of the arteriosclerosis but also its precursor, proper and early treatment should be introduced even in very young individuals [ 4 , 6 ]. There is no consensus as to which technique should be used and which vessel should be examined for the most reliable evaluation of arterial tree stiffening [ 4 , 7 – 11 ]. Recently the two-dimensional speckle-tracking (2DST) technique, which was primarily a cardiac application [ 12 ], has enabled the estimation of arterial wall motion and deformation (strain) during the cardiac cycle [ 3 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral vascular stiffness, assessed with two-dimensional speckle tracking versus the degree of coronary artery calcification, evaluated by tomographic coronary artery calcification index

Podgórski¹,

Grzelak²,

Szymczyk³

et al. 2015

aoms

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IntroductionEven in asymptomatic patients, the result of atherosclerosis progression is deterioration of the function and morphology of the artery wall. Two-dimensional speckle-tracking (2DST) is a sonographic technique that allows for precise evaluation of arterial wall compliance. Together with measurement of intima-media thickness (IMT), it can be applied for quick and non-invasive assessment of the progression of peripheral artery atherosclerosis.Material and methodsFifty-eight patients of mean age 61 years (SD 10.6) underwent cardiac computed tomography (CT) and subsequent ultrasonographic evaluation of the left common carotid artery. The calcium score was calculated according to the Agatston method and compared with IMT, circumferential strain variables assessed by 2DST, conventional arterial stiffness parameters (β-stiffness index and elastic modulus) and clinical data. Intra-observer and inter-observer agreement was evaluated.ResultsStrain variables and IMT differed significantly in patients with calcium score (CS) > 0 and CS = 0. Moreover, they correlated with CS, systolic blood pressure and age of patients. Conventional stiffness parameters were not able to identify the group of patients with calcifications present in the coronary arteries. For the 2DST technique, interclass and intraclass agreements were 84.83% and 94.42% respectively.ConclusionsCircumferential strain variables assessed by 2DST and measurement of IMT can be used for evaluation of peripheral artery deterioration in patients until the 6th decade of life. These parameters reflect the development of calcifications in coronary arteries and, more importantly, can be used for a more detailed estimation of the atherosclerosis risk in patients with CS = 0.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral vascular stiffness, assessed with two-dimensional speckle tracking versus the degree of coronary artery calcification, evaluated by tomographic coronary artery calcification index

Podgórski¹,

Grzelak²,

Szymczyk³

et al. 2015

aoms

View full text Add to dashboard Cite

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“…1 ) [ 28 – 30 ]. Fractional area change and strain and strain rate by VVI were reduced according to age and significantly correlated with conventional parameters of arterial stiffness such as PWV and augmentation index (AIx) [ 29 ]. More importantly, VVI measurements of time to peak strain and strain rate enabled the assessment of the synchronicity of arterial systolic expansion.…”

Section: Novel Technique In Evaluation Of Vascular Function; Strain Imentioning

confidence: 99%

“…Unlike PWV or AIx, asynchronicity of arterial systolic expansion rises steadily with aging and is independent of hemodynamic conditions including heart rate (Figs. 2 and 3 ) [ 29 ]. Therefore, asynchronous arterial expansion could be a more sensitive marker of vascular aging at all ages.…”

Section: Novel Technique In Evaluation Of Vascular Function; Strain Imentioning

confidence: 99%

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Non-invasive assessment of vascular alteration using ultrasound

Yang

2015

Clin Hypertens

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It is well known that arterial function relates to cardiovascular morbidity and mortality. The noninvasive technology for the assessment of arterial function has developed as the importance of prevention of early cardiovascular disease has been emphasized. Over 2-D and Doppler echocardiography, speckle-tracking echocardiography has emerged as a valuable ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function. Recently, several studies have extended its applicability beyond cardiac chambers, such as artery. Measurement of carotid arterial strain with speckle tracking ultrasound has been shown to be feasible and reliable. This review describes the new ultrasound techniques to assess arterial function and their clinical implications.

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Incremental predictive value of carotid arterial strain in patients with stroke

Yang

Kang

Lee

et al. 2018

Int J Cardiovasc Imaging

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Although increased carotid intima-media thickness (IMT) is a well-known risk factor for stroke, carotid IMT alone is not sufficient for risk stratification. The assessment of arterial properties using velocity vector imaging (VVI) represents a new method for quantifying structural changes. We sought to investigate the characteristics and the clinical value of carotid arterial mechanics using VVI in patients with stroke. Fifty male patients (55 ± 5 years) with stroke, 30 healthy age-matched volunteers (54 ± 8 years), and 30 healthy young male volunteers (29 ± 5 years) were evaluated. The peak circumferential strain, strain rate, and the standard deviation of the time to peak strain and strain rate, representing the synchronicity of the arterial expansion, were analyzed using VVI of the left common carotid artery. The circumferential strain and strain rate significantly decreased with age, and patients with stroke showed the lowest degree of strain and strain rate compared with healthy age-matched volunteers. In addition, patients with stroke showed decreased strain and strain rate even in participants with a normal carotid IMT (< 0.8 mm). Although carotid IMT did not improve the incremental predictive value of stroke over that of multiple clinical risk factors (diabetes mellitus, hypertension, coronary artery disease, smoking), adding carotid arterial strain and strain rate provided an incremental predictive value over both multiple risk factors and carotid IMT for stroke. Along with assessment of conventional risk factors, VVI analysis could provide improved risk stratification for stroke.

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Asynchronous arterial systolic expansion as a marker of vascular aging

Abstract: Asynchronous arterial expansion could be a useful discriminative marker of vascular aging independent of individual's age.

Cited by 17 publications

References 25 publications

Peripheral vascular stiffness, assessed with two-dimensional speckle tracking versus the degree of coronary artery calcification, evaluated by tomographic coronary artery calcification index

Peripheral vascular stiffness, assessed with two-dimensional speckle tracking versus the degree of coronary artery calcification, evaluated by tomographic coronary artery calcification index

Non-invasive assessment of vascular alteration using ultrasound

Incremental predictive value of carotid arterial strain in patients with stroke

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