Asymptomatic SARS Coronavirus 2 infection: Invisible yet invincible

Nikolai, Lea A.; Meyer, Christian G.; Kremsner, Peter G.; Velavan, Thirumalaisamy P.

doi:10.1016/j.ijid.2020.08.076

Cited by 194 publications

(175 citation statements)

References 62 publications

(70 reference statements)

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“…Asymptomatic infection has been identi ed as a signi cant factor in the community spread of SARS-CoV-2, which in turn, continues to propagate the pandemic [24]. As discussed previously, patients with cancer are prone to more symptomatic and serious illness.…”

Section: Discussionmentioning

confidence: 98%

Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy

Thakkar

Pradhan

Jindal

et al. 2020

Preprint

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Patients with cancer have been identified in several studies to be at high risk of developing severe COVID-19; however, rates of SARS-CoV-2 IgG seroconversion and its association with cancer types and anti-cancer therapy remain obscure. We conducted a retrospective cohort study in patients with cancer that underwent SARS-CoV-2 IgG testing. Two hundred and sixty-one cancer patients underwent SARS-CoV-2 IgG testing and demonstrated a high rate of seroconversion (92%). However, significantly lower seroconversion was observed in patients with hematologic malignancies (82%), patients that received anti-CD-20 antibody therapy (59%), CAR-T/cellular therapy (33%) and stem cell transplant (60%). Interestingly, all 17 patients that received immunotherapy, including 16 that received anti-PD-1/PD-L1 monoclonal antibodies, developed SARS-Cov-2 IgG antibodies (100% seroconversion). These data show differential rates of seroconversion in specific patient groups and bear importance for clinical monitoring and vaccination strategies that are being developed to mitigate the COVID-19 pandemic

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Section: Discussionmentioning

confidence: 98%

Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy

Thakkar

Pradhan

Jindal

et al. 2020

Preprint

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“…On the other hand, presymptomatic carriers can be defined as cases with no symptoms at the moment of test, but they could develop later. For that reason, presymptomatic carriers only can be detected by retrospective studies ( Nikolai et al, 2020 , Savvides and Siegel, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of COVID-19 in Mexico: Symptomatic profiles and presymptomatic people

Fernández-Rojas¹,

Esparza²,

Campos‐Romero³

et al. 2021

International Journal of Infectious Diseases

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“…First, the cycle thresholds of asymptomatic and symptomatic patients on the Diamond Princess were comparable, thus supporting a similar degree of contagiousness and the need to identify and isolate both populations. 5 Second, SARS-CoV-2 identified with RT-PCR in asymptomatic patients, detected it with cycle thresholds as low as 21.9. 6 Third, two of 114 asymptomatic travelers from Wuhan to Frankfurt, Germany tested positive and had viral growth of their samples.…”

Section: Discussionmentioning

confidence: 99%

“…It appears that asymptomatic positive people fueled the pandemic to persist for months. 4 , 5 The reason that we currently isolate asymptomatic and symptomatic SARS-CoV-2 patients in the hospital is based on the indirect finding that they shed live virus. Thus, the premise of isolating asymptomatic positive patients is to contain the shedding of live virus.…”

Section: Discussionmentioning

confidence: 99%

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Surveillance testing reveals a significant proportion of hospitalized patients with SARS-CoV-2 are asymptomatic

Arnold

Bishop

Oppy

et al. 2021

American Journal of Infection Control

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Background: The proportion of positive patients admitted to acute-care hospitals for reasons other than coronavirus disease-19 (COVID-19) is unknown. These patients potentially put other patients and healthcare workers at risk of infection. Objective: The objective of this study was to define the proportion of asymptomatic patients admitted with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Secondary objectives were to define the positivity rate, reasons for admission, and the geographic distribution in the region. Methods: Universal surveillance testing for SARS-CoV-2 was performed on patients admitted to this hospital over a 12-week period from April 9, 2020 to July 1, 2020. Positive patients were categorized as either symptomatic or asymptomatic as defined by the 11 criteria per the Centers for Disease Control and Prevention. The positivity rate, proportion with and without symptoms, reasons for admission, and geographic distribution in the region were recorded. Results: The positivity rate ranged from 0.8% to 6.2%. The proportion of asymptomatic patients with SARS-CoV-2 was 37%. Asymptomatic patients primarily presented to the hospital because of either trauma or labor. Some clusters in the region were identified of both symptomatic and asymptomatic patients. Conclusions: The proportion of asymptomatic patients admitted with SARS-CoV-2 was significant. Identifying and isolating asymptomatic patients likely prevented exposure and development of hospital-acquired COVID-19 cases among healthcare workers and other patients, supporting the universal surveillance of all admitted patients.

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Asymptomatic SARS Coronavirus 2 infection: Invisible yet invincible

Cited by 194 publications

References 62 publications

Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy

Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy

Epidemiology of COVID-19 in Mexico: Symptomatic profiles and presymptomatic people

Surveillance testing reveals a significant proportion of hospitalized patients with SARS-CoV-2 are asymptomatic

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