Asymptomatic sacroiliitis detected by magnetic resonance enterography in patients with Crohn's disease: prevalence, association with clinical data, and reliability among radiologists in a multicenter study of adult and pediatric population

Cereser, Lorenzo; Zancan, Giovanni; Giovannini, Ivan; Cicciò, Carmelo; Tinazzi, Ilaria; Variola, Angela; Bramuzzo, Matteo; Murru, Flora Maria; Marino, Marco; Tullio, Annarita; Vita, Salvatore De; Girometti, Rossano; Zabotti, Alen

doi:10.1007/s10067-022-06143-w

Cited by 5 publications

(10 citation statements)

References 43 publications

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“…The further studies showed a feasibility of MRE to detect BME, sclerosis, fatty deposits, and also to some extent erosions with ankylosis. 6,13,14,34 However, studies in patients with inflammatory bowel disease, especially with CD, based either on MRE or on MRI, found no significant association between SIJ changes and clinical parameters such as disease duration, behavior, bowel involvement, and BMI. 6,13,14,[34][35][36][37] We also did not find any significant difference in the abovementioned clinical parameters between CD patients with and without SIJ changes.…”

Section: Discussionmentioning

confidence: 99%

“…The interest in this method is constantly growing due to the ability to cover a more significant spectrum of patients and an opportunity to simultaneously investigate intestinal and sacroiliac changes, the relationship of which still needs to be studied. Some previous studies have already reported the ability of MRE to detect BME and structural changes as incidental findings in patients with IBD, with a prevalence of 15%–23.5% 13,14 . In a recent systematic review by Evans et al 15 .…”

Section: Introductionmentioning

confidence: 99%

“…Some previous studies have already reported the ability of MRE to detect BME and structural changes as incidental findings in patients with IBD, with a prevalence of 15%-23.5%. 13,14 In a recent systematic review by Evans et al 15 in 2021, who investigated the prevalence of sacroiliitis in patients with IBD, the clinical relationship between sacroiliitis and CD intestinal forms remains unclear, as no association was found between sacroiliitis, age, number of exacerbations, CD duration, bowel involvement, and behavior.…”

Section: Introductionmentioning

confidence: 99%

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Association between sacroiliac joint forms and subchondral changes in patients with Crohn's disease

Melekh,

Barajas Ordonez,

Melekh

et al. 2024

Int J of Rheum Dis

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AimTo assess the relationship between anatomical variants of sacroiliac joint (SIJ) and subchondral changes detected in magnetic resonance enterography (MRE) in patients with Crohn's disease (CD).MethodsThis was a retrospective study of 60 CD patients, who were divided into two groups: with (n = 16) and without SIJ (n = 44) involvement, depending on the presence of inflammatory (bone marrow edema) and structural changes (sclerosis and erosions) in MRE. Anatomical variants of SIJ were assessed in CT of the abdomen and/or pelvis, distinguishing typical form with convex iliac surface and atypical forms. Univariate and multivariate analyses were performed to reveal an association between joint changes and forms.ResultsOur study included 60 patients (38 males; mean age 38.72 years ± 13.33). Patients with SIJ changes were older (p = .044). No significant differences in CD localization and behavior were found. The most common SIJ lesions were structural changes (in 75% of patients); the main atypical form was the iliosacral complex. The univariate and multivariate analyses showed a significant association of atypical forms with total subchondral changes (odds ratio [OR]: 3.429, 95% confidence interval [CI] 1.043–11.268; p = .042; OR: 5.066, 95% CI: 1.273–20.167; p = .021, respectively), and with structural changes (OR: 4.185, 95% CI: 1.155–15.160; p = .029; OR: 5.986, 95% CI: 1.293–27.700; p = .022, respectively).ConclusionAtypical forms of SIJ are a risk factor for the occurrence of structural joint changes in CD patients. An association between bone marrow edema and atypical forms was not found.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between sacroiliac joint forms and subchondral changes in patients with Crohn's disease

Melekh,

Barajas Ordonez,

Melekh

et al. 2024

Int J of Rheum Dis

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“…However, it would be an appropriate approach to evaluate the axial skeleton in CTs taken for other indications. Evaluation of the sacroiliac joint on lower abdominal CT or MR enterography, which is performed for inflammatory bowel disease, are good examples for this purpose 10,11 . In our study, joints of the patients were evaluated on thorax CT scans performed for lung pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of the sacroiliac joint on lower abdominal CT or MR enterography, which is performed for inflammatory bowel disease, are good examples for this purpose. 10,11 In our study, joints of the patients were evaluated on thorax CT scans performed for lung pathologies. There is no standard method for evaluating the involvement of these joints on CT.…”

Section: Ta B L Ementioning

confidence: 99%

Costovertebral and costotransverse joint involvement in spondyloarthritis

Ata,

Durhan,

Bilgin

et al. 2023

Int J of Rheum Dis

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ObjectivesCostovertebral (CV), costotransverse (CTr), sternoclavicular (SC), and manubriosternal (MS) joints are impacted in spondyloarthritis (SpA) patients; however, clinical aspects of these involvements require additional evaluation.MethodsA total of 281 SpA patients who had undergone chest computed tomography (CT) for any reason between 2010 and 2020 were included in the study. SpA patients were divided into three groups, ankylosing spondylitis (AS), non‐radiographic axial SpA, and psoriatic arthritis. Thirty age‐ and sex‐matched rheumatoid arthritis (RA) patients and 30 non‐rheumatic disease individuals were selected for comparison. An experienced radiologist reviewed 24 CV, 20 CTr, 2 SC, and 1 MS joints from a thorax CT for each patient. All joints were classified as: normal (0); suspicious (1), mild (2), moderate (3), or severe (4).ResultsTotal CV and CTr joint scores differed between diseases (p < .001). Male AS patients had higher CV and CTr scores than female AS patients (male CV score: 52 [range 0–96] and CTr score: 22 [range 0–80]; female CV score: 20 [range 0–96] and CTr score: 12 [range 0–79]). Strong negative correlations were detected in AS patients between chest expansion and CV (r = −0.703 p = .007) and CTr (r = −0.763 p = .002) joint involvement; positive correlations between CV and CTr joints, and modified Stoke Ankylosing Spondylitis Spinal Score (p < .05); and no significant association for MS and SC joints.ConclusionsCV and CTr joint involvement on thorax CT was more severe in AS and negatively affected chest expansion. The use of thorax CT scans performed for other indications in the examination of these joints may be advantageous for the early beginning of rehabilitation programs targeted at maintaining chest mobility.

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Letter to the Editor: “Development and validation of equations for conversion from DAS28ESR and DAS28CRP to the SDAI in patients with rheumatoid arthritis”

Yu,

Qian,

2024

Clin Rheumatol

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Asymptomatic sacroiliitis detected by magnetic resonance enterography in patients with Crohn's disease: prevalence, association with clinical data, and reliability among radiologists in a multicenter study of adult and pediatric population

Cited by 5 publications

References 43 publications

Association between sacroiliac joint forms and subchondral changes in patients with Crohn's disease

Association between sacroiliac joint forms and subchondral changes in patients with Crohn's disease

Costovertebral and costotransverse joint involvement in spondyloarthritis

Letter to the Editor: “Development and validation of equations for conversion from DAS28ESR and DAS28CRP to the SDAI in patients with rheumatoid arthritis”

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