Asymptomatic Plasmodium falciparum infection evades triggering a host transcriptomic response

Prah, Diana Ahu; Dunican, Claire; Amoah, Linda Eva; Marjaneh, Mahdi Moradi; Kaforou, Myrsini; Nordgren, Ann; Jones‐Warner, William; Aniweh, Yaw; Awandare, Gordon A.; Cunnington, Aubrey J.; Hafalla, Julius Clemence R.

doi:10.1016/j.jinf.2023.06.013

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Gene expression tests may also allow discrimination between symptomatic vs incidental parasitaemia. For example, Prah et al [ 7 ] compared whole-blood gene expression in Ghanaian children with symptomatic malaria, asymptomatic parasitaemia, and healthy uninfected controls. Comparison with uninfected controls found many hundreds of differentially expressed genes in those with symptomatic malaria but no differentially expressed genes between the uninfected and those with asymptomatic parasitaemia.…”

Section: Diagnosticsmentioning

confidence: 99%

“…Transcriptomic studies have been used extensively in malaria to examine host response to infection, parasite pathogenic mechanisms, and the complex interactions between the two [ 3–5 ]. These studies have focused on single cells [ 6 ] and bulk tissues during natural infections [ 7 ] and also in controlled human malaria infection studies, where healthy volunteers are intentionally infected with malaria parasites and monitored under careful clinical supervision [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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The malarial blood transcriptome: translational applications

Dunican,

Andradi-Brown,

Ebmeier

et al. 2024

Biochemical Society Transactions

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The blood transcriptome of malaria patients has been used extensively to elucidate the pathophysiological mechanisms and host immune responses to disease, identify candidate diagnostic and prognostic biomarkers, and reveal new therapeutic targets for drug discovery. This review gives a high-level overview of the three main translational applications of these studies (diagnostics, prognostics, and therapeutics) by summarising recent literature and outlining the main limitations and future directions of each application. It highlights the need for consistent and accurate definitions of disease states and subject groups and discusses how prognostic studies must distinguish clearly between analyses that attempt to predict future disease states and those which attempt to discriminate between current disease states (classification). Lastly it examines how many promising therapeutics fail due to the choice of imperfect animal models for pre-clinical testing and lack of appropriate validation studies in humans, and how future transcriptional studies may be utilised to overcome some of these limitations.

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Section: Diagnosticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The malarial blood transcriptome: translational applications

Dunican,

Andradi-Brown,

Ebmeier

et al. 2024

Biochemical Society Transactions

Self Cite

View full text Add to dashboard Cite

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The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

Boyle,

Engwerda,

Jagannathan

2024

Nat Rev Immunol

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Asymptomatic Low-Density Plasmodium falciparum Infections: Parasites Under the Host's Immune Radar?

Prah,

Laryea-Akrong

2024

The Journal of Infectious Diseases

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A large body of evidence suggests that low parasite carriage in Plasmodium falciparum asymptomatic infection is required for the maintenance of malaria immunity. However, the fact that treating such infections has little to no impact on subsequent clinical malaria is rarely noted. In this paper, we review data and argue that low-density parasite carriage in asymptomatic infection may not support host immune processes and that parasites are virtually under the host's immunological radar. We also discuss factors that may be constraining parasitemia in asymptomatic infections from reaching the threshold required to cause clinical symptoms. A thorough understanding of this infectious reservoir is essential for malaria control and eradication because asymptomatic infections contribute significantly to Plasmodium transmission.

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Asymptomatic Plasmodium falciparum infection evades triggering a host transcriptomic response

Cited by 5 publications

References 12 publications

The malarial blood transcriptome: translational applications

The malarial blood transcriptome: translational applications

The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

Asymptomatic Low-Density Plasmodium falciparum Infections: Parasites Under the Host's Immune Radar?

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