Asymptomatic Hyperuricemia and Metabolically Unhealthy Obesity: A Cross-Sectional Analysis in the Tianning Cohort

Yu, Jia; Sun, Hongyan; Zhu, Jian; Wei, Xin‐Tong; Shi, Hang; Shen, Bin; Ren, Liyun; Zhang, Rongyan; Zhang, Mingzhi; Peng, Hao

doi:10.2147/dmso.s301363

Cited by 13 publications

(16 citation statements)

References 48 publications

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“…Previous studies have shown that obesity and its phenotypes are significantly associated with the risk of hyperuricemia, and the relationship are sex-specific and age-specific differences ( 29 – 31 ). In the Chinese population, Tian et al suggested that the MHOO phenotype was significantly associated with the risk of hyperuricemia only in women and not in men from the China Health and Nutrition Survey ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the Chinese population, Tian et al suggested that the MHOO phenotype was significantly associated with the risk of hyperuricemia only in women and not in men from the China Health and Nutrition Survey ( 30 ). Yu et al found that MUOO, in comparison with MHOO, was significantly associated with hyperuricemia in Chinese adults ( 29 ). High serum UA levels have long been considered a potential master conductor in metabolic syndrome and fat storage ( 17 , 32 ), but it is still unknown whether serum UA is a risk factor of obesity-related metabolic phenotypes in Chinese population.…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

et al. 2022

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PurposeSerum uric acid (UA) not only affects the development of obesity but also alters the metabolic status in obese subjects; thus we investigated the relationship between serum UA and the overweight/obese metabolic phenotypes.MethodsThe demographic, biochemical, and hematological data were collected for 12,876 patients undergoing routine physical examination, and 6,912 participants were enrolled in our study. Participants were classified into four obesity metabolic phenotypes according to their BMI and the presence of metabolic syndrome: metabolically healthy overweight/obese (MHOO), metabolically healthy and normal weighted (MHNW), metabolically abnormal and overweight/obese (MAOO), and metabolically abnormal but normal weighted (MANW). Univariate and multivariate logistic regression analysis, stratified analysis, and also interaction analysis were conducted to analyze the relationship between serum UA and obesity metabolic phenotypes.ResultsMultivariable logistic regression analysis showed that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes relative to MHNW. After adjusting for the confounding factors, the odds ratios (OR) for individuals with hyperuricemia to be MHOO, MANW, and MAOO phenotypes were 1.86 (1.42–2.45), 2.30 (1.44–3.66), and 3.15 (2.34–4.24), respectively. The ORs for having MHOO, MANW, and MAOO increased 6% [OR: 1.06 (1.05–1.07), P < 0.0001], 5% [OR: 1.05 (1.03–1.07), P < 0.0001], and 11% [OR: 1.11 (1.10–1.13), P < 0.0001] for each 10 unit (μmol/L) of increase in serum UA level. Stratification analysis as well as an interaction test showed that sex and age did not interfere with the association of hyperuricemia with each metabolic phenotype. In terms of the components of the metabolic syndrome, after adjusting for other confounding factors including all of the metabolic indicators except itself, hyperuricemia was positively associated with increased BMI [OR: 1.66 (1.32–2.09), P < 0.0001], hypertriglyceridemia [OR: 1.56 (1.21–2.02), P = 0.0006], and hypertension [OR: 1.22 (1.03–1.46), P = 0.0233], while it had no significant association with hyperglycemia and low HDL-C (all P > 0.05).ConclusionIn our study, we discovered that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes, and this relationship was independent of sex and age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

et al. 2022

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“…Other cross-sectional studies also indicated positive associations between BMI and HUA (30,31). BMI has been acknowledged to have a causal and independent effect on elevating the SUA level (5,30,32). However, BMI does not differentiate fat-free mass from adipose tissue (33) and may have a low sensitivity for predicting BFP (34).…”

Section: Discussionmentioning

confidence: 99%

“…In a large survey of 310,577 Japanese middle-aged adults, obese participants were found to have a 1.33-3.76-fold higher risk of HUA in comparison with their nonobese counterparts (29). Other cross-sectional studies also indicated positive associations between BMI and HUA (30,31). BMI has been acknowledged to have a causal and independent effect on elevating the SUA level (5,30,32).…”

Section: Discussionmentioning

confidence: 99%

Joint Effect of Beer, Spirits Intake, and Excess Adiposity on Hyperuricemia Among Chinese Male Adults: Evidence From the China National Health Survey

Pan

Ren

et al. 2022

Front. Nutr.

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Alcohol intake and excess adiposity are associated with serum uric acid (SUA), but their interaction effect on hyperuricemia (HUA) remains unclear. Using data from the China National Health Survey (CNHS) (2012–2017), we analyzed the additive interaction of beer, spirits intake, excess adiposity [measured by body mass index (BMI), body fat percentage (BFP), and visceral fat index (VFI)] with HUA among male participants aged 20–80 from mainland China. The relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP), and the synergy index (SI) were calculated to assess the interaction effect on the additive scale. Both RERI and AP larger than 0 and SI larger than 1 indicate a positive additive interaction. Among 12,592 male participants, the mean SUA level was 367.1 ± 85.5 μmol/L and 24.1% were HUA. Overweight/obese men who were presently drinking spirits had an odds ratio (OR) of 3.20 (95%CI: 2.71–3.79) than the never drink group, with RERI, AP, and SI of 0.45 (95%CI: 0.08–0.81), 0.14 (95%CI: 0.03–0.25), and 1.25 (95%CI: 1.02–1.54), respectively. However, although combined exposures on beer intake and excess adiposity had the highest OR compared with no beer intake and nonobese participants, there was no additive interaction, with RERI, AP, and SI in the overweight/obesity and the beer intake group of 0.58 (−0.41–1.57), 0.17 (−0.08–0.41), and 1.30 (0.85–1.97), respectively. Other excess adiposity indexes revealed similar estimates. Our findings suggested that the exposures of both excess adiposity and alcohol drink could result in an additive interaction effect on HUA: the combined risk of excess adiposity with spirits intake but not with beer was greater than the sum of the effects among Chinese male adults.

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“…Obesity is one of the major risk factors for HUA, and body mass index (BMI) was positively correlated with serum uric acid levels in previous studies (R = 0.96; p < 0.00001; Shirasawa et al, 2020;Yu et al, 2021). Tai et al (2020) has reported increased risk of gout when urate genetic risk scores are higher in low/normal-weight (OR: 2.89, 95% CI: 2.42-3.47), overweight (OR 3.09, 95% CI: 2.84-3.36), and obese individuals (OR 2.65, 95% CI: 2.46-2.86) based on BMI.…”

Section: Introductionmentioning

confidence: 95%

Association of ABCG2 rs2231142 Allele and BMI With Hyperuricemia in an East Asian Population

Chen

Lin

et al. 2021

Front. Genet.

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Objectives: Genetic variants and obesity are risk factors for hyperuricemia (HUA). Recent genome-wide association studies have identified ABCG2 rs2231142 as one of the most prominent genetic variants for HUA in an East Asian population. Nevertheless, no large-scale studies have demonstrated any interactive effects between this variant and obesity on serum urate level in Asians. This study aimed to determine the interaction of ABCG2 rs2231142 variant and body mass index (BMI) and its effect on risk of HUA in an East Asian population.Methods: The study was conducted using the Taiwan Biobank database, a population-based biomedical research database of patients with Taiwanese Han Chinese ancestry aged 30–70years between September 2014 and May 2017. Detailed physical information on participants were collected by questionnaires and genotyping using Affymetrix TWB 650K SNP chip. The primary outcome was HUA, defined as a serum uric acid level>7.0mg/dl. Odds ratio (OR) of HUA was analyzed using logistic regression models and the effects of interaction between ABCG2 rs2231142 variants and BMI on serum uric acid level were explored.Results: We identified 25,245 subjects, 4,228 (16.75%) of whom had HUA. The prevalence of HUA was 30% in men and 3.8% in women. The risk of HUA was significantly associated with ABCG2 rs2231142 risk T allele, with more HUA in TT genotype (OR: 2.40, 95% CI: 2.11–2.72, p<0.001) and TG genotype (OR: 1.64, 95% CI: 1.51–1.78, p<0.001) in men, and TT genotype (OR: 2.42, 95% CI: 1.83–3.20, p<0.001) and TG genotype (OR: 1.82, 95% CI: 1.46–2.23, p<0.001) in women, compared with their counterparts. Moreover, we found a strong genetic-environmental interaction associated with the risk of HUA. There was increased risk of HUA by the interaction of ABCG2 rs2231142 variant and BMI for TT genotype (OR: 7.42, 95% CI: 2.54–21.7, p<0.001) and TG genotype (OR: 4.25, 95% CI: 2.13–8.47, p<0.001) in men compared with the GG genotype in men, and for TT genotype (OR: 25.43, 95% CI: 3.75–172.41, p<0.001) and TG genotype (OR: 3.05, 95% CI: 0.79–11.71, p=0.011) in women compared with the GG genotype in women.Conclusion: The risk of HUA was markedly increased by the interaction of ABCG2 rs2231142 variant and BMI, both in men and in women. Body weight control and reduction in BMI are recommended in high-risk patients with the ABCG2 rs2231142 risk T allele.

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Asymptomatic Hyperuricemia and Metabolically Unhealthy Obesity: A Cross-Sectional Analysis in the Tianning Cohort

Cited by 13 publications

References 48 publications

The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

Joint Effect of Beer, Spirits Intake, and Excess Adiposity on Hyperuricemia Among Chinese Male Adults: Evidence From the China National Health Survey

Association of ABCG2 rs2231142 Allele and BMI With Hyperuricemia in an East Asian Population

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