Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?

Zenda, Takahiro; Araki, Ichiro; Sasaki, Motoko

doi:10.1007/s12328-019-00950-6

Cited by 3 publications

(2 citation statements)

References 31 publications

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“… 67 There were still, however, cases without any underlying process that could be identified despite an extensive workup. 68 , 69 …”

Section: Resultsmentioning

confidence: 99%

Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis

Jiao¹,

Zhang²

2022

J Clin Transl Pathol

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Post-infantile giant cell hepatitis (PIGCH) is a rare disease entity in adults with a multifactorial etiology and widely variable clinical courses and outcomes. The factors associated with the worse outcomes of this disease entity are still unclear. We identified 68 PIGCH patients by searching PubMed and performed meta-analysis. Among the 68 patients, 32% of the cases were associated with autoimmune disorders, followed by 21% associated with viral infections, 10% with medication, and 7% with malignancy. Twenty-four percent of the patients had more than one etiological factor, and 6% had other uncommon etiologies or an etiology that could not be identified. At the time of this report, 17 patients had died of the disease (poor outcome), and 51 patients remained alive with the disease (good outcome). Compared to the patients with a good outcome, the patients with a poor outcome were characterized by older age, lower levels of platelets and albumin, higher level of total bilirubin, and a diffuse distribution pattern of giant cells in the liver. There were no differences in gender distribution, aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, etiological distribution, or other histological features, including interface hepatitis, necrosis, lobular inflammation, portal inflammation, cholestasis, or fibrosis. Further studies would be needed to better understand the disease mechanisms and unmask any additional etiological factors and targeted therapies.

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“… 67 There were still, however, cases without any underlying process that could be identified despite an extensive workup. 68 , 69 …”

Section: Resultsmentioning

confidence: 99%

Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis

Jiao¹,

Zhang²

2022

J Clin Transl Pathol

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“…3 The clinical course of PIGCH varies broadly, ranging from minimal symptoms and complete recovery after treatment, to rapid progression to cirrhosis or fatal liver failure despite standard clinical care. [5][6][7][8][9][10] The clinicopathologic features are poorly understood. Here, we performed a multi-institutional retrospective study to characterize the clinical, histologic, and laboratory features that might predict the outcomes of PIGCH.…”

Section: Introductionmentioning

confidence: 99%

Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases

Jiao,

Chezar,

Zhang

et al. 2023

Modern Pathology

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Autoimmune post-infantile giant cell hepatitis: a case report and review of the literature

Xiao

Gao

Deschênes

2021

CanLivJ

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Giant cell hepatitis (GCH) is a rare entity in adults that is characterized by large multinucleated hepatocyte formation and parenchymal inflammation. We present a case of acute liver failure in a 33-year-old woman secondary to autoimmune hepatitis (AIH). A liver biopsy revealed submassive hepatocyte necrosis consistent with GCH. We conducted a literature review of 187 reported cases of post-infantile GCH in adults. AIH was the most commonly reported cause of GCH, but GCH was associated with a wide spectrum of etiologies, including infections, rheumatological diseases, hematological diseases, malignancies, and medications. The severity of disease can range from mild hepatitis to fulminant hepatic failure. The mortality rate among the cases in the literature was 18.82%. GCH is managed by treating the underlying cause, and ribavirin has been proposed as a treatment option for idiopathic GCH. A small number of patients progress to requiring orthotopic liver transplant, but recurrence is possible post-transplant.

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Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?

Cited by 3 publications

References 31 publications

Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis

Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis

Postinfantile Giant Cell Hepatitis in Native and Allograft Livers: A Multi-Institutional Clinicopathologic Study of 70 Cases

Autoimmune post-infantile giant cell hepatitis: a case report and review of the literature

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