Asymptomatic COVID‐19 infection in late pregnancy indicated no vertical transmission

Abstract

This study is to investigate the clinical characteristics of late pregnancy with asymptomatic 2019 novel coronavirus disease (COVID-19) infection, evaluate the outcome of maternal and fetal prognosis, and identify the evidence of intrauterine vertical transmission. A 22-years-old pregnant woman with asymptomatic COVID-19 infection who was admitted to our hospital on 11 February 2020 was enrolled in this study. Clinical data including laboratory test results and chest computed tomography (CT) scanning were collected and reviewed. Diagnosis of late pregnancy with asymptomatic COVID-19 infection was made. Lumbar anesthesia for cesarean section was performed and a female baby was delivered uneventfully, with the Apgar score of 9 to 10 points. Three times of COVID-19 nucleic acid test for the baby was negative after delivery. The puerpera returned to normal after the operation and two times of throat swab COVID-19 nucleic acid test were all negative after antiviral therapy. We reported an asymptomatic COVID-19 pregnant woman with detailed clinical information and our result indicated that for late pregnant women with asymptomatic COVID-19 infection, there might be no intrauterine infection caused by vertical transmission. K E Y W O R D Sasymptomatic COVID-19 infection, intrauterine infection, late pregnancy, vertical transmission

Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS‐CoV‐2 infection among hospitalized pregnant women: A systematic review

“…Serum biochemistry results were reported in 37 studies encompassing 381 women respectively 4,5,9–11,13–15,17,18,20,21,25,29,30,33–36,39,41,44–50,53,56,57–60,63,66 . In this group, raised serum C‐reactive protein was reported among 275 (72.2%) women, lymphopenia among 179 (47.0%) women, and transaminitis among 93 (24.4%) women.…”

“…Seven (1.9%) women were aged 40 years or older. Presenting symptoms were reported in 55 studies, comprising 515 pregnant women 4,5,7,11–19,21–30,32–57 . Of these, the most common symptoms at presentation were fever (n=273, 53.0%), cough (n=224, 43.5%), myalgia/malaise (n=79, 15.3%), dyspnea (n=64, 12.4%), diarrhea (n=18, 3.5%), and sore throat (n=18, 3.5%), regardless of gestational age.…”

“…Four women presented with reduced fetal movements and three with prepartum hemorrhage. Notably, 68 (10.7%) women in 10 studies were asymptomatic on admission 4,5,12,13,21,37,41,53,55,64 …”

“…Chest imaging findings were reported in 42 studies (n=274 women), and comprised 267 computed tomography (CT) scans of the chest, 15 plain chest X‐rays, and 5 CT pulmonary angiogram (CTPA) examinations 4,5,9–11,13,15–17,22–30,33–37,39–41,44,45,49–51,53,57–60,62–66 . In 26 studies, totaling 221 women from China with mild COVID‐19, 196 (88.7%) had abnormal chest CT and X‐ray findings, of whom 17 (8.7%) were asymptomatic at the time of radiologic evaluation 4,5,9–11,13,16,29,34–37,40,41,44,45,49–51,53,57‐60,62–64 . Abnormal pulmonary findings among pregnant women with mild disease included focal unilateral or bilateral ground glass opacities, whereas diffuse, bilateral ground glass opacities with subpleural involvement and pleural effusion were observed among all women with severe and critical COVID‐19.…”

Factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: A systematic review and meta-analysis

“…The characteristics of included trials were presented in Table 1 . A total of 269 patients from 47 studies [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] were included in our meta-analysis. The mean age of operative patients with COVID-19 was 50.91 [95% CI, 42.49; 59.34], and 49% [95% CI, 0.33, 0.65] patients were female.…”