2022
DOI: 10.12688/gatesopenres.13357.2
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Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression.

Abstract: Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per country. Among those without symptoms, the rate of pre-symptomatic illness is unclear, and potential predictors of progression for symptom development are unknown. Our objective was to delineate the natural evolution of asymptomatic SARS-CoV-2 infection in elders and ide… Show more

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Cited by 7 publications
(3 citation statements)
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“…However, on closer analysis, we found all asymptomatic infections in this age group were in cases aged over 70, while the symptomatic patients ranged in age from 65 to 68 years, with a mean age difference of 6.1 years (95% CI 3.7-8.5, p < 0.001) between those with symptoms and those without. This is consistent with reports of higher asymptomatic presentations of infections in older populations over 75 years or with comorbidity, where 65-68% of cases failed to develop symptoms [19,20].…”
Section: Discussionsupporting
confidence: 92%
“…However, on closer analysis, we found all asymptomatic infections in this age group were in cases aged over 70, while the symptomatic patients ranged in age from 65 to 68 years, with a mean age difference of 6.1 years (95% CI 3.7-8.5, p < 0.001) between those with symptoms and those without. This is consistent with reports of higher asymptomatic presentations of infections in older populations over 75 years or with comorbidity, where 65-68% of cases failed to develop symptoms [19,20].…”
Section: Discussionsupporting
confidence: 92%
“…Dementia may further be a risk factor for the spread of the virus, since adherence to sanitary rules and physical distancing measures is very difficult for these patients due to their cognitive state and limited possibilities to cope with changing circumstances [ 36 ]. Additionally, a substantial number of the elder people with SARS-CoV-2 infection is asymptomatic or has atypical symptoms [ 5 , 6 , 37 ], which therefore make the diagnosis difficult, especially in those with dementia.…”
Section: Discussionmentioning
confidence: 99%
“…This was commonly reported by people during the period of COVID. Some COVID patients went through the disease with severe symptoms despite being in the best of health before infection, while some chronically ill elderly people showed no symptoms ( Zhang et al, 2020 ; Esteban et al, 2021 ). The host response following the exposure is linked to genetic predisposition, disruption of the individual’s microbiome ( Pichon, Lina & Josset, 2017 ), being in high-risk group ( Walker et al, 2022 ) and effective immune surveillance.…”
Section: Introductionmentioning
confidence: 99%