Asymptomatic cervicocerebral atherosclerosis, intracranial vascular resistance and cognition: The AsIA-Neuropsychology Study

López-Olóriz, Jorge; López‐Cancio, Elena; Arenillas, Juan F.; Hernández, María del C. Valdés; Jiménez, Marta; Dorado, Laura; Barrios, Maite; Soriano-Raya, Juan José; Miralbell, Júlia; Cáceres, Cynthia; Forés, Rosa; Pera, Guillem; Dávalos, Antoni; Mataró, María

doi:10.1016/j.atherosclerosis.2013.08.011

Cited by 27 publications

(22 citation statements)

References 30 publications

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“…These results are in line with our previous report in Barcelona-AsIA study with 747 subjects (in the age range 51-91), which showed an independent association between the intracranial vascular resistance measured by MCA-PI and cognition [18]. To the best of our knowledge, this is the only study that focuses on the association between MCA-PI and cognition in community samples.…”

Section: Discussionsupporting

confidence: 82%

“…In a small group of hypertensive and diabetic elders, Purkayastha et al [17] found an association between MCA-PI and WMH, but not with miscrostructural brain changes measured by MRI-DTI. In the Barcelona-AsIA-Neuropsychology Study, including 747 asymptomatic subjects with a wide age range (51-91 years), we found an independent association between MCA-PI and lower cognitive performance [18]. The relationship between MCA-PI and microstructural DTI-WM changes of concrete tracts in a population-based sample has never been explored.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion Tensor Imaging, Intracranial Vascular Resistance and Cognition in Middle-Aged Asymptomatic Subjects

López-Olóriz

López‐Cancio²,

Arenillas³

et al. 2014

Cerebrovasc Dis

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Background: The contribution of traditional vascular risk factors to cognitive impairment and dementia is well known. However, in order to obtain possible targets for prevention of vascular cognitive impairment (VCI), it may be important to identify other early and noninvasive markers in asymptomatic middle-aged adults. The calculation of middle cerebral artery-pulsatility index (MCA-PI) is an ultrasonologic, noninvasive, validated and easily reproducible technique to assess increased distal resistance to blood flow. This study aims to assess the relationship between MCA-PI, microstructural white matter (WM) integrity and cognition in a middle-aged asymptomatic population. Methods: Ninety-five participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50-65 years old, free from dementia and without history of vascular disease. Transcranial color-coded duplex ultrasound examination was performed to assess MCA-PI as a measure of vascular resistance. WM integrity was evaluated by fractional anisotropy (FA) measurements of diffusion tensor images (DTI) acquired on a 3T-MRI. The neuropsychological battery was specifically selected to be sensitive to VCI, and included tests that were grouped into six cognitive domains: executive functioning, attention, verbal fluency, memory, visuospatial skills and psychomotor speed. A multivariate linear regression model adjusted for age, gender, years of education, diabetes and hypertension was performed. Results: MCA-PI was significantly associated with WM disintegration in different tracts (fornix, corticospinal and anterior thalamic), all p < 0.05 uncorrected. Both mean MCA-PI and mean FA of those significant tracts were independently associated with poor performance in attention, psychomotor speed, and visuospatial skills after adjustment for age, gender, years of education, and vascular risk factors (all p < 0.05). MCA-PI was independently associated with lower scores in all cognitive domains, except for visuospatial skills. Conclusions: Our data suggest that MCA-PI may be related to WM disintegration and early vascular cognitive impairment in middle-aged subjects. Although further prospective studies are needed to provide evidence for its validity in longitudinal studies, our results support the proposal of including MCA-PI as part of clinical assessment in order to identify targets for VCI prevention.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging, Intracranial Vascular Resistance and Cognition in Middle-Aged Asymptomatic Subjects

López-Olóriz

López‐Cancio²,

Arenillas³

et al. 2014

Cerebrovasc Dis

Self Cite

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“…Increased intracranial vascular resistance has previously been shown to be associated with poorer cognitive performance in dementia-free individuals [39]. Thus, use of peripheral rather than central nervous system measures of AWF is a limitation of the present study.…”

Section: Discussionmentioning

confidence: 90%

“…Nevertheless, the heterogenic effect of vasculopathy on different organs, as demonstrated by the 10-year difference between the peak incidence of myocardial infarction and that of stroke [40, 41], suggests that cerebral vessels are affected at a later stage than coronary vessels and stresses the relevance of the relationship of peripheral extra-cranial vessels function with cognition. An additional limitation is lack of data on carotid artery stenosis, previously demonstrated to be associated with cognitive function, independently of intracranial vascular changes (e.g., silent MRI infarcts, white matter lesions) [39, 42–44], and lack of structural imaging of brain parenchyma and vasculature, precluding any conclusions about the relationship of peripheral AWF with these factors. The study included only male subjects, limiting the generalizability of the findings to women.…”

Section: Discussionmentioning

confidence: 99%

Arterial Wall Function is Associated with Cognitive Performance Primarily in Elderly with Type 2 Diabetes

Ravona‐Springer

Haratz

Tanné

et al. 2015

JAD

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Regression analyses compared 41 type 2 diabetes (T2D) and 131 non-T2D cognitively normal elderly males on the associations of arterial wall function measures [large artery elasticity index (LAEI), small artery elasticity index (SAEI), systemic vascular resistance (SVR), and total vascular impedance (TVI)] with cognitive performance (memory, language, and executive functions), controlling for socio-demographic and cardiovascular factors. Higher LAEI and lower TVI were significantly associated with better executive functions performance in T2D but not in non-T2D subjects. Lower TVI was more associated with better language performance in T2D. Results suggest that arterial wall function is associated with cognition in T2D.

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“…A consensus has now been reached that early detection and treatment of classic vascular risk factors reduce their impact on the epidemiology of dementia (9,10). Although intimal medial thickness (IMT), a marker of early atherosclerosis, is associated with cognitive decline and can be used to measure subclinical vascular disease (11), previous studies have mainly focused on community population samples with or without a history of stroke (12–14).…”

Section: Introductionmentioning

confidence: 99%

Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study

Xiang

2017

Experimental and Therapeutic Medicine

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Although cerebrovascular diseases have been considered as risk factors for cognitive decline and dementia, the associations between atherosclerosis and Alzheimer's disease (AD) have not been fully examined and remain controversial. The aim of this three-year prospective study was to investigate whether arotid artery atherosclerosis accelerates cognitive impairment in AD patients. The association of carotid intimal medial thickness (IMT) with prospective trajectories of cognitive function was assessed among 521 patients with light to moderate AD, and 437 AD patients were followed up annually for 3 years. Participants underwent initial carotid ultrasonography and repeated neuropsychological testing every year. Mixed-effects regression analyses were adjusted to estimate the effect of carotid IMT and other adjusting variables. The results of the present study indicated that carotid IMT was significantly associated with various measures of cognitive function. Furthermore, AD patients with higher carotid IMT values had a faster decline in cognitive scores in a variety of neuropsychological tests, particularly in verbal and non-verbal memory, semantic fluency and executive function. The present prospective study showed that carotid atherosclerosis is a predictive factor regarding the progression of cognitive impairment in AD patients, suggesting that early detection and treatment of vascular risk factors may prevent or at least postpone the evolution of the disease.

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Asymptomatic cervicocerebral atherosclerosis, intracranial vascular resistance and cognition: The AsIA-Neuropsychology Study

Cited by 27 publications

References 30 publications

Diffusion Tensor Imaging, Intracranial Vascular Resistance and Cognition in Middle-Aged Asymptomatic Subjects

Diffusion Tensor Imaging, Intracranial Vascular Resistance and Cognition in Middle-Aged Asymptomatic Subjects

Arterial Wall Function is Associated with Cognitive Performance Primarily in Elderly with Type 2 Diabetes

Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study

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