Asymptomatic carotid lesions add to cardiovascular risk prediction

Novo, Salvatore; Visconti, Claudia; Amoroso, G; Corrado, Egle; Fazio, Giovanni; Muratori, Ida Maria; Tantillo, R; Lunetta, Monica; D’Angelo, Luciana; Novo, Giuseppina

doi:10.1097/hjr.0b013e328337ccbd

Cited by 20 publications

(10 citation statements)

References 20 publications

(23 reference statements)

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“…Carotid Doppler is a simple and cheap method to assess state of the vessels and detect early vascular damage . Although the HCV chronically infected patients are usually characterised by a favourable lipoprotein profile, low platelet count and low blood pressure, several studies suggested a high prevalence of carotid atherosclerosis due to the pro‐inflammatory and metabolic alteration, insulin resistance/diabetes proper of these patients .…”

Section: Discussionmentioning

confidence: 99%

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Novo

Macaione

Giannitrapani

et al. 2018

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Novo

Macaione

Giannitrapani

et al. 2018

Aliment Pharmacol Ther

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“…It is suitable for large population study, because this measurement is non-invasive, low-cost and convenient. Moreover, CIMT has been used in clinical trials to evaluate the efficacy of anti-diabetic, anti-hyperlipidemia and anti-hypertensive treatments [5-8]. …”

Section: Introductionmentioning

confidence: 99%

Gender difference in carotid intima-media thickness in type 2 diabetic patients: a 4-year follow-up study

Zhao

Liu

Zhang

et al. 2012

Cardiovasc Diabetol

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BackgroundDifferent population studies have reported gender difference in carotid intima-media thickness (CIMT), which is proved to be a risk factor of cardiovascular diseases. However, few longitudinal researches examine this gender difference in type 2 diabetes mellitus (T2DM) patients. Therefore, we prospectively analyzed CIMT in T2DM patients over a 4-year follow-up period.Methods355 T2DM patients (mean age 59 years; 54.9% women) were included in the present study. CIMT were measured using Color Doppler ultrasound. CIMT was measured at baseline (CIMT) in 2006 and at follow-up in 2010. Biochemical and clinical measurements were collected at baseline.ResultsMean value of CIMT1 and CIMT2 were 0.740 ± 0.148 mm and 0.842 ± 0.179 mm, respectively. Men had higher CIMT than women both at baseline and at follow-up (CIMT1: 0.762 ± 0.149 vs 0.723 ± 0.146 mm, P = 0.0149; CIMT2: 0.880 ± 0.189 vs 0.810 ± 0.164 mm, P = 0.0002). Mean annual progression of CIMT (dCIMT) was 0.025 ± 0.022 mm/year. dCIMT was larger in men than in women (0.030 ± 0.025 vs 0.022 ± 0.019 mm, P = 0.0006). In multiple regression analyses, age was an independent risk factor of CIMT in both genders, while dCIMT was associated with age only in men.ConclusionsGender difference in CIMT was confirmed in T2DM patients. Moreover, impact of ageing on CIMT progression only existed in men, which might be the reason that gender difference in CIMT increased with age.

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“…A thicker IMT predicts coronary heart disease [28], stroke [29], and myocardial infarction [29,31]. A 5,5 years-follow-up showed that the risk of myocardial necrosis increases for about 10- 15% just if IMT increases for 0,1 mm while the risk of stroke increases for about 13- 18% [37]. Moreover other studies underlined that the Metabolic Syndrome could produce a more rapid deterioration of brain function, because it seems to be related to a low gray matter cerebral blood flow (GM-CBF) and to a lower immediate memory function if compared to control subjects [38].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, preclinical atherosclerosis added to traditional risk factors can improve the cardiovascular risk prediction [37,47], especially in presence of metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up

Novo

Peritore

Trovato

et al. 2013

Cardiovasc Diabetol

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BackgroundIntima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events.PatientsWe studied a population of 529 asymptomatic patients (age 62 ± 12.8 years), divided into two groups of subjects with and without Metabolic Syndrome (MetS).MethodsAll patients, at baseline, have had a carotid ultrasound evaluation and classified in two subgroups: the first one without atherosclerotic lesions and the second one with preclinical atherosclerosis (increased IMT or asymptomatic carotid plaque). Cardiovascular endpoints were investigated in a 20-years follow-up.ResultsThere were 242 cardiovascular events: 144 among patients with MetS and 98 among in healthy controls (57.4% vs. 35.2%; P < 0.0001). 63 events occurred in patients with normal carotid arteries, while 179 events occurred in patients with preclinical atherosclerosis (31.8% vs. 54.1%; P < 0.0001). Of the 144 total events occurred in patients with MetS, 36 happened in the subgroup with normal carotid arteries and 108 in the subgroup with preclinical atherosclerosis (45% vs. 63.15%; P = 0.009). 98 events occurred in patients without MetS, of which 27 in the subgroup with normal carotid arteries and 71 in the subgroup with preclinical atherosclerosis (22.88% vs. 44.37%; P = 0.0003). In addition, considering the 63 total events occurred in patients without atherosclerotic lesions, 36 events were recorded in the subgroup with MetS and 27 events in the subgroup without MetS (45% vs. 22.88%; P = 0.0019). Finally, in 179 total events recorded in patients with preclinical carotid atherosclerosis, 108 happened in the subgroup with MetS and 71 happened in the subgroup without MetS (63.15% vs. 44.37%; P = 0.0009). The Kaplan-Meier function showed an improved survival in patients without atherosclerotic lesions compared with patients with carotid ultrasound alterations (P = 0.01, HR: 0.7366, CI: 0.5479 to 0.9904).ConclusionsPreclinical atherosclerosis leads to an increased risk of cardiovascular events, especially if it is associated with MetS.

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Asymptomatic carotid lesions add to cardiovascular risk prediction

Abstract: In our experience, the incidence of CV events is enhanced in patients with subclinical-ATS. Increased IMT and ACP predict CV events and improve the risk stratification of asymptomatic patients aged greater than 45 years and with a cluster of RFs, in a long-term follow-up.

Cited by 20 publications

References 20 publications

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Gender difference in carotid intima-media thickness in type 2 diabetic patients: a 4-year follow-up study

Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up

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