Asymptomatic Bacteriuria: Change of the Common Opinion

Захарова, И. Н.; Османов, И. М.; Мумладзе, Э. Б.; Мачнева, Е. Б.; Тамбиева, Е В; Бекмурзаева, Г Б

doi:10.21518/2079-701x-2017-19-162-167

Med. sov.

2017

DOI: 10.21518/2079-701x-2017-19-162-167

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Asymptomatic Bacteriuria: Change of the Common Opinion

И. Н. Захарова¹,

И. М. Османов²,

Э. Б. Мумладзе³

et al.

Abstract: НЕФРОЛОГИЯ/УРОЛОГИЯ Определение. Бессимптомная (асимптоматическая) бактериурия представляет собой выделение с мочой бактерий в количестве, соответствующем их росту в мочевых путях, при отсутствии симптомов патологии мочевых путей [1, 2]. Критерии ИМП у детей, утвержденные европейскими экспертами, представлены в таблице 1. В отечественных рекомендациях дано следующее определение: «Бактериурия-присутствие бактерий в моче (более 10 5 КОЕ в 1 мл мочи), выделенной из мочевого пузыря. Асимптоматической бактериурией … Show more

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Cited by 5 publications

References 25 publications

(31 reference statements)

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From bacteriuria to the urinary tract microbiome: the evolution of the views of researchers and clinicians

et al. 2018

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The preservation of the human urinary tract integrity in interaction with microorganisms depends on the balance of many components: the viability of nonspecific protective factors of the urinary tract mucosa, the virulence factors of microorganisms, the intensity of the innate immune response of the urinary tract tissue to the presence of microorganisms, the mutual impact of the microand macro-organism upon each other that is directed towards creation of a normal microbiome, and not inflammation. Most of these factors are genetically determined both by microorganisms and humans. The article presents modern data of Russian and foreign literature devoted to the description of factors supporting the homeostasis of the urinary tract in interacting with microorganisms. The authors emphasise a key role of these data in the practice of clinicians, including paediatricians and paediatric nephrologists, family doctors.

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From bacteriuria to the urinary tract microbiome: the evolution of the views of researchers and clinicians

et al. 2018

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Laboratory markers of urinary tract infection in children: current state and prospects

Цуцаева

Захарова

Eremenko³

et al. 2022

Medicinskij sovet

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Urinary tract infection (UTI) is a common and important clinical problem in all age groups. Diagnosis of UTI without localization is not difficult, while the differential diagnosis of UTI is complicated by the lack of specific criteria for pyelonephritis and cystitis. The presence of certain clinical symptoms in combination with a positive bacteriological examination of urine does not allow us to reliably determine the localization of the inflammatory process in the urinary system, which is important due to the different approaches to the treatment of pyelonephritis and cystitis. The review considers in detail the data of studies demonstrating insufficient sensitivity and specificity of the accepted markers of urinary tract infection. Studies have found that ESR and CRP cannot act as specific markers for UTI, especially in children with fever. It has been shown that the procalcitonin test can be considered as such a marker, however, a limited number of studies and a noticeable heterogeneity between studies do not allow us to state this fact definitely. In this regard, it is necessary to search for modern, more accurate biomarkers, that allow differentiating pyelonephritis and cystitis at the earliest stages. The article presents data of modern studies, demonstrating the role of cytokines as biomarkers of UTI, showing their role in differentiating UTI of the lower and upper parts. In addition, the potential role of antimicrobial peptides as diagnostic markers of UTI is considered.

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Diagnosis of asymptomatic bacteriuria in pregnant women: Rational approaches

Sukhorukova,

Stepankova,

Pokusaeva

et al. 2023

Vrach

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Asymptomatic bacteriuria (AB) during pregnancy has a negative impact on its course and also affects obstetric and perinatal outcomes. Objective. To optimize the diagnosis of AB in pregnant women to prevent possible negative effects of asymptomatic infections on obstetric and perinatal outcomes. Subjects and methods. A single-center prospective trial included 101 pregnant women, who in the first trimester had AB in different titers being detected by a screening bacteriological examination of their urine specimen. All the patients underwent repeated urinary bacteriological examination in compliance with all the requirements for this examination. The specific features of the course of pregnancy and perinatal outcomes were analyzed in women with bacteriuria detected in various titers. A control group consisted of 50 women without a history of urinary tract infections. Results. The repeated examination confirmed that 9 (9.0%) patients had bacteriuria in a titer ≥105 CFU/ml; 65 (70.6%) had this condition in a titer of 102–104 CFU/ml; no growth of etiologically significant microorganisms was found in 27 (29.4%) examinees. Studying the results of primary urine cultures revealed monoinfection in 72.3% of cases; a combination of two microorganisms was noted in 27.7%. The regional structure of the repeatedly isolated uropathogens is mainly represented by Enterobacteriales. The bacteriological examination of urine before antibacterial therapy repeatedly confirmed AB in a significant titer only in 9 patients (95% confidence interval, 0.042-0.162; p=0.029). Bacteriuria even through single separation of an uropathogen in a low titer during pregnancy is associated with an increased risk for mild anemia and hypertension. Conclusion. Even the single detection of uropathogens in the urine of pregnant women, including those with a low diagnostic titer of 102–104 CFU/ml is associated with the unfavorable course of pregnancy.

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Asymptomatic Bacteriuria: Change of the Common Opinion

Cited by 5 publications

References 25 publications

From bacteriuria to the urinary tract microbiome: the evolution of the views of researchers and clinicians

From bacteriuria to the urinary tract microbiome: the evolution of the views of researchers and clinicians

Laboratory markers of urinary tract infection in children: current state and prospects

Diagnosis of asymptomatic bacteriuria in pregnant women: Rational approaches

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