Asymptomatic Bacteriuria, antimicrobial susceptibility pattern and associated risk factors among pregnant women attending antenatal care in Assosa General Hospital, Western Ethiopia

Abu, Duresa; Abula, Teferra; Zewdu, Tesfu; Berhanu, Muluken; Sahilu, Tamiru

doi:10.1186/s12866-021-02417-6

Cited by 11 publications

(21 citation statements)

References 15 publications

(12 reference statements)

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“…Furthermore, the present study shows that women with a history of UTI before pregnancy had a higher risk of ASB during pregnancy. This result is aligned with previous investigations that have been conducted in India and Ethiopia, 6 , 11 , 13 and it could be attributed to the fact that UTI is a recurrent infection and that there is a possibility of having remnant antibiotic-resistant organisms from a previous UTI attack. 11 , 13…”

Section: Discussionsupporting

confidence: 91%

“…This is comparable to the prevalence of ASB in other developed countries (2–10%). 2 Furthermore, the ASB prevalence in this study was lower than reports from other countries like Ethiopia (13.78–19.90%), 1 , 6 , 11 Nigeria (18.21%), 12 India (17.40%), 13 Egypt (10%), 14 Iran (08.70%), 3 Cameroon (07.80%), 4 United Arab Emirates (04.80%), 15 and Bangladesh (04.50%). 7 The differences between the prevalence of ASB in this study and others could be explained by variations in methodologies and sampling, setting of the study (primary care, hospital level of care, or community-based), patient’s background, socioeconomic levels, social habits, genital hygienic practices, and methods of urine collection among patients from different studies.…”

Section: Discussionmentioning

confidence: 50%

“…Data from several countries in Africa demonstrated that the prevalence was 5.5% to 24.7%. 1 , 5 , 6 In Bangladesh, the prevalence of ASB in early pregnancy was 4.5%. 7 A meta-analysis of 31 Iranian studies concluded that the estimated prevalence of ASB in pregnant women in Iran was 8.7% (95% CI 7.2 to 10.4).…”

Section: Introductionmentioning

confidence: 99%

“… 3 Although the data concerning the factors associated with ASB are conflicting across the countries, some studies reported that increasing maternal age, parity, low educational status, presence of diabetes, and history of UTI were associated with an increased risk of ASB in pregnant women. 1 , 3 , 6 …”

Section: Introductionmentioning

confidence: 99%

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The Epidemiology, Associated Factors and Bacterial Profile of Asymptomatic Bacteriuria in Pregnant Women: A Retrospective Chart Review Study in Saudi Arabia

AlShamlan¹,

AlOmar²,

Aldossary³

et al. 2022

IJWH

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Purpose Asymptomatic bacteriuria (ASB) is the presence of significant amounts of bacteria within the urinary tract in the absence of urinary tract infection (UTI) symptoms, resulting in negative neonatal and pregnancy consequences. This study determined the prevalence, bacteriology patterns, and associated factors with ASB among pregnant women in both primary and hospital levels of care in the Eastern Province of Saudi Arabia. Methods This retrospective chart review study included pregnant women between 18 and 50 years who performed the screening urine culture test during their first antenatal visit between 2017 and 2021, without UTI symptoms. The collected data involved the demographic, medical, and obstetric characteristics, and urine culture results. T-tests and chi-squared tests were used for bivariate associations followed by binary logistic regression models. Results ASB was positive among 03.42% of the 6471 pregnant women included in the study. Logistic regression revealed that the risk of positive ASB increased in pregnant women in the first and second trimesters (OR = 2.04, 95% CI = 1.41–2.93 and OR= 1.50, 95% CI = 1.03–2.19, respectively), as well as pregnant women with a history of previous UTI (OR = 2.98, 95% CI = 2.14–4.15). The predominant organism isolates were E. coli , followed by GBS, Klebsiella pneumoniae , and Enterococcus faecalis . Conclusion With limited data on ASB among pregnant women in Saudi Arabia, findings from the current study could help decision-makers in the country assess the epidemiological characteristics of the condition. Further study is recommended to investigate the susceptibility patterns of commonly prescribed antibiotics with different uropathogens to guide the clinicians who deal with these cases. Additionally, a large national study across the other regions in the kingdom is suggested to calculate the prevalence of ASB in Saudi Arabia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Epidemiology, Associated Factors and Bacterial Profile of Asymptomatic Bacteriuria in Pregnant Women: A Retrospective Chart Review Study in Saudi Arabia

AlShamlan¹,

AlOmar²,

Aldossary³

et al. 2022

IJWH

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“…The pure cultured single colonies were coated on glass slides for Gram staining [ 17 ] and observed under an oil immersion microscope.…”

Section: Methodsmentioning

confidence: 99%

Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Geese

Kang

Zhou

Jin

2022

Veterinary Sciences

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Rothia nasimurium was known previously as an opportunistic pathogen of animals. However, there are few reports regarding the pathogenicity of Rothia nasimurium. In September 2020, geese contracted a disease of unknown cause which brought economic losses to a farm in Jiangsu Province, China, prompting a series of investigations. The bacterium was isolated, cultured, and purified, and then identified using Gram staining, biochemical tests, matrix-assisted laser desorption/ionization time of flight mass spectrometry, and 16S rRNA sequence analysis. After determining the obtained bacteria species, antibiotic susceptibility tests and animal regression experiments were carried out. A strain of bacterium was successfully isolated from the livers of the diseased geese, which was identified as a strain of the Gram-positive bacterium Rothia nasimurium according to the 16S rRNA sequencing results. By indexing references, no goose was reported to have been infected with Rothia nasimurium. The antibiotic susceptibility testing showed that only four antibiotics (amikacin, cefazolin, fosfomycin, and ampicillin/sulbactam) could effectively inhibit the growth of the Rothia nasimurium strain. The animal regression experiments showed that the novel isolated strain could infect goslings, and it also causes serious depilation of goslings. The results of the manuscript expanded the range of pathogenic microorganisms in geese, which is helpful to develop methods for avian endemic control.

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Antimicrobial resistance and ESBL production in uropathogenic Escherichia coli: a systematic review and meta-analysis in Ethiopia

Asmare,

Erkihun,

Abebe

et al. 2024

JAC-Antimicrobial Resistance

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Background Antimicrobial resistance (AMR) is a serious threat to global health systems. Escherichia coli is a major cause of urinary tract infections (UTIs). Understanding the AMR patterns of uropathogenic E. coli (UPEC) is crucial for effective public health interventions worldwide. Objectives This systematic review and meta-analysis aimed to consolidate existing research and provide a comprehensive information on AMR UPEC in Ethiopia. Methods We systematically searched databases such as PubMed, Web of Science, and Science Direct, along with including articles from Google Scholar. Data were extracted into Microsoft Excel and analysed using STATA 17.0. Cohen’s kappa was computed to assess reviewer agreement, while the I2 statistic evaluated heterogeneity. Egger’s tests were conducted to detect publication bias, and random-effects models were utilized to estimate the pooled resistance, with AMR rates for each antibiotic pooled separately. Results UPEC showed resistance rates, ranging from 3.64% (95% CI: −4.38% to 11.67%) for amikacin to 85.32% (95% CI: 78.6%–92.04%) for ampicillin. Highest resistance was to ampicillin (85.32%), followed by amoxicillin at 82.52% (95% CI: 74.3%–90.74%), tetracycline at 60.67% (95% CI: 51.53%–69.81%) and trimethoprim/sulfamethoxazole at 57.17% (95% CI: 49.93%–64.42%). Conversely, resistance rates were lower for amikacin at 3.64% and meropenem at 5.26% (95% CI: 2.64%–7.88%). UPEC demonstrated a pooled MDR rate of 79.17% (95% CI: 70.32%–88.01%) and a pooled ESBL production rate of 29.16% (95% CI: 22.36%–38.55%). Conclusions High levels of AMR were observed in UPEC strains, highlighting a critical public health issue requiring urgent action through robust antimicrobial stewardship and surveillance to preserve effective UTI treatment options.

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Asymptomatic Bacteriuria, antimicrobial susceptibility pattern and associated risk factors among pregnant women attending antenatal care in Assosa General Hospital, Western Ethiopia

Cited by 11 publications

References 15 publications

The Epidemiology, Associated Factors and Bacterial Profile of Asymptomatic Bacteriuria in Pregnant Women: A Retrospective Chart Review Study in Saudi Arabia

The Epidemiology, Associated Factors and Bacterial Profile of Asymptomatic Bacteriuria in Pregnant Women: A Retrospective Chart Review Study in Saudi Arabia

Rothia nasimurium as a Cause of Disease: First Isolation from Farmed Geese

Antimicrobial resistance and ESBL production in uropathogenic Escherichia coli: a systematic review and meta-analysis in Ethiopia

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