Asymptomatic bacteriuria and antibiotic resistance profile in children with neurogenic bladder who require clean intermittent catheterization

Ben‐David, Reuben; Carroll, Fred; Kornitzer, Emmanuel; Dekalo, Snir; Ben‐Chaim, Jacob; Cleper, Roxana; Bar-Yosef, Yuval

doi:10.1038/s41393-021-00679-5

Cited by 7 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although CIC is associated with significantly fewer complications than indwelling catheters [ 38 ], asymptomatic bacteriuria in patients undergoing CIC is common [ 12 ], and considerations regarding the risk and impact of repeated UTIs, especially in immunosuppressed children, have emerged repeatedly over time [ 3 , 39 ]. In accordance with previous publications, the number of febrile UTIs in our study was associated with poorer long-term kidney graft survival ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation

Marcou,

Galiano,

Tzschoppe

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Congenital anomalies of the kidneys and urinary tract (CAKUTs) are one of the most prevalent primary causes of end-stage renal disease (ESRD) in young children, and approximately one-third of these children present with lower urinary tract dysfunction (LUTD). Many children with LUTD require therapy with clean intermittent catheterization (CIC). CIC commonly leads to bacteriuria, and considerations have arisen regarding whether CIC in immunosuppressed children is safe or whether repeated febrile urinary tract infections (UTIs) may lead to the deterioration of kidney graft function. Material and Methods: We retrospectively reviewed all cases of primary kidney transplantation performed in our center between 2001 and 2020 in recipients aged less than twelve years. The number of episodes of febrile UTIs as well as the long-term kidney graft survival of children undergoing CIC were compared to those of children with urological causes of ESRD not undergoing CIC, as well as to those of children with nonurological causes of ESRD. Results: Following successful kidney transplantation in 41 children, CIC was needed in 8 of these patients. These 8 children undergoing CIC had significantly more episodes of febrile UTIs than did the 18 children with a nonurological cause of ESRD (p = 0.04) but not the 15 children with a urological cause of ESRD who did not need to undergo CIC (p = 0.19). Despite being associated with a higher rate of febrile UTIs, CIC was not identified as a risk factor for long-term kidney graft survival, and long-term graft survival did not significantly differ between the three groups at a median follow-up of 124 months. Conclusions: Our study demonstrates that, under regular medical care, CIC following pediatric transplantation is safe and is not associated with a higher rate of long-term graft loss.

show abstract

Section: Discussionmentioning

confidence: 99%

“…CIC commonly leads to bacteriuria [ 12 ]. Bacteriuria combined with immunosuppression following pediatric kidney transplantation is assumed to be a risk factor for the development of febrile UTIs or could even lead to sepsis, which could affect long-term graft survival or even patient survival [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation

Marcou,

Galiano,

Tzschoppe

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…38 These children are subjected to multiple procedures, hospital admissions and non-urinary infectious complications leading to the acquisition of nosocomial strains and the development of resistant strains through antibiotic treatments. 39 There is no consensus for prevention, diagnosis, and treatment of UTIs in these patients. CIC increases the possibility of bacteriuria by introducing microorganisms into the bladder.…”

Section: Urinary Tract Infectionsmentioning

confidence: 99%

“…In children with NB, catheter‐associated UTIs are the most frequent complication with a prevalence of 40–60% and incidence of 1–10 UTIs/year 38 . These children are subjected to multiple procedures, hospital admissions and non‐urinary infectious complications leading to the acquisition of nosocomial strains and the development of resistant strains through antibiotic treatments 39 …”

Section: Urinary System Problems In Children With Hmvmentioning

confidence: 99%

Causes and management of urinary system problems in children on long‐term home invasive mechanical ventilation

Soylu,

Kavukcu

2024

Pediatric Pulmonology

View full text Add to dashboard Cite

Many ventilator‐dependent children have comorbid conditions including urinary tract disorders. We aimed to present a focused review of the literature describing the causes and management of urinary system problems in children with long‐term home mechanical ventilation. We performed a literature search in PubMed/MEDLINE, Scopus, and Web of Science with keywords “children,” “home mechanical ventilation,” “urinary system,” “urinary tract,” “neurogenic bladder,” “clean intermittent catheterization,” “urinary tract infection,” “urolithiasis,” and “acute kidney injury.” We included original articles, reviews, guidelines, and case reports published in English. Ventilator‐dependent children may have neurogenic bladder/bowel dysfunction which renders them prone to urinary tract infection, high bladder pressure, vesicoureteral reflux, hydronephrosis, and renal dysfunction. These children require bladder catheterization, medications affecting parasympathetic/sympathetic nervous systems, or surgical procedures to prevent urinary infections, and to maintain continence and renal functions. However, bladder catheterization or surgical procedures like augmentation cystoplasty may also be complicated with urinary infections, urolithiasis, or urethral strictures. Urolithiasis frequency is also increased due to immobilization‐related hypercalciuria, hypocitraturia caused by antiepileptic drugs, urinary stasis, and urinary infections. On the other hand, mechanical ventilation can impair renal function by reduction of cardiac output, redistribution of intrarenal blood flow and stimulation of sympathetic and hormonal pathways. Children requiring long‐term invasive home mechanical ventilation may have other comorbid conditions, including urinary system diseases, which become manifest as these patients are being kept alive due to the advances in ventilation strategies. These children must be carefully observed for urological complications and managed accordingly to prevent kidney injury.

show abstract

The urological evaluation and management of neurogenic bladder in children and adolescents—what every pediatric nephrologist needs to know

et al. 2023

View full text Add to dashboard Cite

Asymptomatic bacteriuria and antibiotic resistance profile in children with neurogenic bladder who require clean intermittent catheterization

Cited by 7 publications

References 18 publications

Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation

Clean Intermittent Catheterization in Children under 12 Years Does Not Have a Negative Impact on Long-Term Graft Survival following Pediatric Kidney Transplantation

Causes and management of urinary system problems in children on long‐term home invasive mechanical ventilation

The urological evaluation and management of neurogenic bladder in children and adolescents—what every pediatric nephrologist needs to know

Contact Info

Product

Resources

About