Asymptomatic bacteriuria among elderly and middle-aged rural community-dwellers in South-Western Nigeria

Olowe, O. A.; Makanjuola, Olufunmilola Bamidele; Olabiyi, KO; Akinwusi, PO; Alebiosu, CO; Isawumi, MA; Hassan, MB; Asekun-Olarinmoye, E. O.; Adebimpe, WO; Adewole, TA

doi:10.2147/idr.s44724

Cited by 3 publications

(4 citation statements)

References 11 publications

(22 reference statements)

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“…The high prevalence among the subjects might be due to contaminants from procedural error or perennial skin. However, significantly higher level of bacteriuria observed among the females is in agreement with the findings of several earlier studies[ 6 14 15 20 ] and it might be related to the short course of the female urethra and its proximity to the anorectal region. [ 21 22 ]…”

Section: Discussionsupporting

confidence: 92%

“…This observation is in contrast to several reports, which identified E. coli as the most common uropathogen causing asymptomatic bacteriuria. [ 15 23 24 ] However, this study aligns with the findings of Dada-Adegbola and Muili[ 25 ] who reported K. pneumoniae as the leading urinary pathogen. Furthermore, the increasing isolation of S. aureus as one of the major causes of UTI has also been reported, thereby suggesting the importance of these bacteria in UTIs.…”

Section: Discussionsupporting

confidence: 90%

“…[ 14 ] in Keffi (North Central) and Olowe et al . [ 15 ] in Oshogbo (South West) Nigeria, among similar individuals without overt clinical symptoms. The high prevalence among the subjects might be due to contaminants from procedural error or perennial skin.…”

Section: Discussionmentioning

confidence: 99%

“…The study of asymptomatic bacteriuria among University students and other healthy individuals in the community have been very few in Nigeria, with reports from Ibadan (South West), Keffi (North Central) and Port Harcourt (South-South) while there is none from Bayelsa State. [ 14 15 16 ] Thus, this study of determining the bacterial profile and antibiotic resistance patterns of uropathogens among asymptomatic students of Niger Delta University in Amassoma, Bayelsa state, Nigeria will both contribute to the knowledge in this field and serve as a means of providing guideline for the empirical treatment of UTIs in this area of Nigeria.…”

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confidence: 99%

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Virulence and antimicrobial resistance of common urinary bacteria from asymptomatic students of Niger Delta University, Amassoma, Bayelsa State, Nigeria

Onanuga

Selekere

2016

J Pharm Bioall Sci

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Background:Asymptomatic bacteriuria frequently occurs among all ages with the possibility of developing into urinary tract infections, and the antimicrobial resistance patterns of the etiologic organisms are essential for appropriate therapy. Thus, we investigated the virulence and antimicrobial resistance patterns of common urinary bacteria in asymptomatic students of Niger Delta University, Amassoma, Bayelsa State, Nigeria in a cross-sectional study.Materials and Methods:Clean catch mid-stream early morning urine samples collected from 200 asymptomatic University students of aged ranges 15–30 years were cultured, screened and common bacteria were identified using standard microbiological procedures. The isolates were screened for hemolysin production and their susceptibility to antibiotics was determined using standard disc assay method.Results:A total prevalence rate of 52.0% significant bacteriuria was detected and it was significantly higher among the female with a weak association (χ2 = 6.01, phi = 0.173, P = 0.014). The Klebsiella pneumoniae and Staphylococcus aureus isolates were most frequently encountered among the isolated bacteria and 18 (12.7%) of all the bacterial isolates produced hemolysins. All the bacterial isolates exhibited 50–100% resistance to the tested beta-lactam antibiotics, tetracycline and co-trimoxazole. The isolated bacteria were 85-100% multi-drug resistant. However, most of the isolates were generally susceptible to gentamicin and ofloxacin. The phenotypic detection of extended-spectrum beta-lactamases was 9 (9.6%) among the tested Gram-negative bacterial isolates.Conclusions:The observed high proportions of multidrug resistant urinary bacteria among asymptomatic University students call for the need of greater control of antibiotic use in this study area.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Virulence and antimicrobial resistance of common urinary bacteria from asymptomatic students of Niger Delta University, Amassoma, Bayelsa State, Nigeria

Onanuga

Selekere

2016

J Pharm Bioall Sci

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Detection of bacteriuria among human immunodeficiency virus seropositive individuals in Osogbo, south-western Nigeria

Olowe¹,

Ojo-Johnson²,

Makanjuola³

et al. 2015

European Journal of Microbiology and Immunology

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Human immunodeficiency virus-positive individuals are at increased risk of both asymptomatic and symptomatic urinary tract infections. The aim of this study was to determine the prevalence of asymptomatic bacteriuria (ASB) in HIV-positive individuals, its associated factors including any correlation with the CD4 count of the patient, and the antibiotic susceptibility pattern of the isolated organisms. Midstream urine and blood samples were collected from 242 consenting HIV-positive patients who were attending routine follow-up clinic during the six-month period of the study. Microscopy, culture, and antibiotic susceptibility testing of the samples were carried out following standard protocols, and CD4 counts were also determined. Fifty one (21.1%) of the 242 individuals had significant bacteriuria. The predominant organism was Klebsiella spp. (35%) followed by Escherichia coli (31%). Prevalence of bacteriuria was higher in the women. Low CD4 counts and young age were significantly associated with the presence of bacteriuria. ASB prevalence is high in this population and related to the CD4 count level.

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Asymptomatic bacteriuria in an apparently healthy population and its relation to hypertension

Odetoyin¹,

Olaniran²,

Afolayan³

et al. 2018

Af J Clin Exp Micro

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Background Hypertension is a major health problem in sub-Sahara Africa. Several studies have suggested a role of asymptomatic bacteriuria (ASB) in the aetiology of hypertension, but there is a dearth of information on this association in Africa where the burden of hypertension is high. We investigated the prevalence of asymptomatic bacteriuria, its association with hypertension and determined the antibiotic resistance patterns of implicated bacterial isolates in an urban community of Ile-Ife. Methods One hundred and seventy-four apparently healthy individuals were investigated for ASB. Relevant information was obtained from them with standard proforma. Their Blood pressure was measured with a standard mercury sphygmomanometer. All samples were processed on cysteine lactose electrolyte deficient medium and chocolate agar. Antimicrobial susceptibility testing was done using Kirby-Bauer disk diffusion technique. Results Fifty (28.7%) individuals were positive for ASB. ASB was commonly detected among the female subjects (χ 2 =5.619; p-value = 0.01777), and among individuals in the age group of 50-59 years. Those that were hypertensive were two and a half times more likely to have ASB (Odd ratio=2.5; p-value=0.01369; CI=1.19-5.35). The highest percentage of hypertensive female participants with ASB was found in the age group of 30-39 years (33.3%) while among the male participants, the highest percentage was found in the age group of 60-69 years (9.5%). Escherichia coli (n=13; 26%) and Staphylococcus aureus (n=13; 26%) were the commonest organisms implicated in ASB. The majority of the isolates (>90%) were multidrug resistant. Isolates of Escherichia coli were commonly resistant to ampicillin (83.3%), ceftriaxone (72.7%) and cefepime (66.7%). Isolates of Staphylococcus aureus were all (100%) resistant to erythromycin, cloxacillin and streptomycin. All isolates were least resistant to cotrimoxazole (<8%). Conclusion Women as well as men in the age group of 50-59 years were more likely to develop ASB. ASB could be contributing to the rising incidence of hypertension in this environment. Co-occurrence of hypertension and ASB portends a grave problem for apparently healthy individuals in this environment.

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Asymptomatic bacteriuria among elderly and middle-aged rural community-dwellers in South-Western Nigeria

Cited by 3 publications

References 11 publications

Virulence and antimicrobial resistance of common urinary bacteria from asymptomatic students of Niger Delta University, Amassoma, Bayelsa State, Nigeria

Virulence and antimicrobial resistance of common urinary bacteria from asymptomatic students of Niger Delta University, Amassoma, Bayelsa State, Nigeria

Detection of bacteriuria among human immunodeficiency virus seropositive individuals in Osogbo, south-western Nigeria

Asymptomatic bacteriuria in an apparently healthy population and its relation to hypertension

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