Asymmetry of tremor intensity and frequency in Parkinson's disease and essential tremor

Farkas, Zsuzsanna; Csillik, Anita; Szirmai, Imre; Kamondi, Anita

doi:10.1016/j.parkreldis.2005.07.008

Cited by 39 publications

(45 citation statements)

References 29 publications

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“…As expected from electromyographic findings in the context of DT (Jedynak et al, 1991), we observed a broader range of frequencies in patients with DT (peak dispersion, ≥3Hz) than in those with PD-T or ET. Still, frequency dispersion was higher in the PD-T group members (2.5-3.5 Hz) than in the group with ET (<2.5 Hz), as found in an earlier accelerometric study (Farkas et al, 2006). Third criterion: spectral coherence.…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L I F Bove supporting

confidence: 58%

“…Accelerometric signals were digitized (100 Hz) and Fourier transformed through proprietary software (DOMINO light; SOMNOmedics). Thus, from three-dimensional (frequency-intensity-time) software-generated graphs, a single investigator (blinded to diagnosis) was able to deduce the following tremor-related indices: intensity (amplitude), center frequency, frequency dispersion (center frequency range accounting for 66% of total spectrum power) and spectrum coherence (coherence of tremor spectra obtained second by second during data acquisition) (Timmer et al, 1996;Farkas et al, 2006;Scanlon et al, 2013;van der Stouwe et al, 2016).…”

Section: Tremor Recording and Analysismentioning

confidence: 99%

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A role for accelerometry in the differential diagnosis of tremor syndromes

Bove¹

2018

Functional Neurology

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SummaryAccelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. All the patients underwent dopamine transporter imaging (by means of single-photon emission computed tomography) and triaxial accelerometric tremor analysis. The latter revealed groupwise differences in tremor frequency, peak dispersion, spectral coherence, unilaterality and resting vs action tremor amplitude. From the above, five diagnostic criteria were extrapolated for each condition. Receiver operating characteristic curves, depicting criteriabased scoring of each tremor type, showed negligible declines in specificity for scores ≥4 in patients with ET or DT and scores ≥3 in patients with PD-T, thus providing a simple scoring method (accelerometrically derived) for differential diagnosis of the principal tremor syndromes.

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Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L I F Bove supporting

confidence: 58%

Section: Tremor Recording and Analysismentioning

confidence: 99%

A role for accelerometry in the differential diagnosis of tremor syndromes

Bove¹

2018

Functional Neurology

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“…An inverse correlation between tremor intensity and centre frequency was found in ET patients while patients with PD showed only significant correlation between centre frequency and the hand with more severe tremor, not in the other hand (Machowska-Majchrzak et al, 2012). Other studies reported a significant inverse correlation between tremor intensity and centre frequency in both hands in patients with PD (Farkas et al, 2006). Further investigation on developing differential diagnosis on tremor intensity and frequency between ET and PD is needed.…”

Section: Current Approaches For Diagnosis Of Et and Pdmentioning

confidence: 80%

“…Studies examined asymmetry of tremors on the hands of PT and ET patients, and demonstrated that the intensity of tremors was significantly asymmetric in both diseases while the frequency (number of repetitions per second) were more symmetric in ET and asymmetric in PD (Farkas et al, 2006). The different type of tremors between ET and PD were also reported by independent investigations.…”

Section: Current Approaches For Diagnosis Of Et and Pdmentioning

confidence: 99%

Mini Review: linkages between essential tremor and Parkinson’s disease?

Wu¹,

Ding²,

Gao³

et al. 2013

Front. Cell. Neurosci.

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Essential tremor (ET) and Parkinson’s disease (PD) are two of the most common movement disorders. Tremors are the primary symptoms of ET and of some PD patients, the two are often mistaken for each other. Especially since there are no available differentiate tests for the tremor of ET or PD, the early diagnoses mainly based on clinical assessments of medical symptoms, family and medication history, and examination by physicians. There is increasing evidence suggesting an association between ET and PD, such as a similar tremor frequency, overlapping resting tremors (a typical PD tremor), postural tremors (mainly in ET patients) in both ET and PD patients, and many ET patients develop PD later in life. Although it is difficult to make a differential diagnosis of ET and tremor-dominant PD based on clinical assessment, recent developments of objective measurements, such as brain imaging, neuropathology, and genetic analysis, has opened a helpful window for distinguishing ET from PD. In this mini review, we included literatures of ET and PD studies and discussed various advanced methods for differential diagnosis between ET and PD such as neuroimaging, genetic markers, tremor intensity and frequency, and drug-responses.

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“…Preliminary studies in patients with Parkinson's disease (PD) have shown the ability of CATSYS to discriminate pathologic from physiologic (normal) tremor in PD patients versus healthy controls [5]. Using bilateral measurements taken with CATSYS, Farkas et al [6] were able to distinguish between the two most common tremor types, parkinsonian and essential tremor (ET), even at low tremor intensities. Our group has published the results of a pilot study of pre- and intraoperative objective quantification of parkinsonian symptoms during high-frequency deep brain stimulation (DBS) using permanently implanted brain electrodes in the subthalamic nucleus for the treatment of PD [7].…”

Section: Introductionmentioning

confidence: 99%

Objective Quantification of Neuromotor Symptoms in Parkinson's Disease: Implementation of a Portable, Computerized Measurement Tool

Papapetropoulos

Katzen

Scanlon

et al. 2010

Parkinson's Disease

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Quantification of neuromotor symptoms with device-based measures provides a useful supplement to clinical evaluation. Research using the CATSYS has established its utility as a computerized measurement system to quantify neuromotor function. The primary objective of this study is to provide technical guidance on the use of the CATSYS in Parkinson's disease (PD). Forty-four patients with idiopathic PD and 28 healthy controls were prospectively recruited and evaluated with CATSYS, a portable, Windows-based system consisting of a data logger and four different sensors (tremor pen, touch recording plate, reaction time handle, and force plate for balance recording) for quantification of neuromotor functions. CATSYS discriminated between PD and controls on measurements of rest/postural tremor, pronation/supination, finger tapping, simple reaction time, and postural sway intensity and velocity. CATSYS measurements using the proposed test battery were associated with relevant clinician-rated Unified Parkinson's disease rating scale (UPDRS) items assessing tremor and bradykinesia. More work is warranted to establish CATSYS as a diagnostic/monitoring instrument in movement disorders using the proposed technical approaches.

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Asymmetry of tremor intensity and frequency in Parkinson's disease and essential tremor

Cited by 39 publications

References 29 publications

A role for accelerometry in the differential diagnosis of tremor syndromes

A role for accelerometry in the differential diagnosis of tremor syndromes

Mini Review: linkages between essential tremor and Parkinson’s disease?

Objective Quantification of Neuromotor Symptoms in Parkinson's Disease: Implementation of a Portable, Computerized Measurement Tool

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