Asymmetry in prevalence of femoral but not carotid atherosclerosis

Bossuyt, Jelle; Bortel, Luc M. Van; Backer, Tine De; Velde, Sandrien Van de; Azermai, Majda; Segers, Patrick; Buyzere, Marc De; daele, Caroline Van; Rietzschel, Ernst

doi:10.1097/hjh.0000000000000205

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…36 This hypothesis is even supported by differences between the distribution of atherosclerotic plaques in carotid and femoral sites already highlighted by previous authors. For example, Bossuyt et al observed a significant right-left difference in IMT of CFA but not of CCA and suggested a possible role of local geometry in the development of atherosclerosis 37 ; however, this side difference has not been observed in our series. This idea is also strengthened by pathology and biochemical studies: Pathology studies demonstrated that atherosclerotic plaques sited in different segments of the arterial tree have commonalities in cell types, but their relative numbers and amount of connective tissue and lipids can vary considerably 36 ; biochemical studies proved a different correlation between circulating lipoprotein and femoral plaques in comparison with carotid plaques.…”

Section: Discussioncontrasting

confidence: 79%

Femoral Artery Ultrasound Examination

et al. 2016

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We compared intima-media thickness (IMT) and the prevalence of plaques in the common carotid artery (CCA) and common femoral artery (CFA) in apparently healthy participants. This multicenter study included 322 participants (59.9% female; age 20-78 years, mean 52.1 ± 15.3 years) who underwent Echo-color Doppler examination of the CCA and CFA bilaterally. Prevalence and composition of plaque were recorded. A significant ( P < .01) difference between mean CCA-IMT and mean CFA-IMT was detected (0.70 vs 0.73 mm). Plaque prevalence was significantly higher in the CFA compared to the CCA (40.7% vs 30.4%). Atherosclerotic plaques were found in both CFA and CCA in 46% of the cases, solely in CFA in 38%, and in CCA alone in 17%. The observed difference in plaque prevalence was even greater when only fibrolipid isolated plaques were considered (CFA 39.4% vs CCA 22.1%). In a healthy general population, atherosclerotic plaques were present in the CFA but not in the CCA in over one-third of the cases. Further studies must confirm whether ultrasonography of the CFA might be introduced in the screening protocols for cardiovascular risk assessment.

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Section: Discussioncontrasting

confidence: 79%

Femoral Artery Ultrasound Examination

et al. 2016

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“…On the other hand, at the femoral bifurcation, asymmetry of atheromatous plaques is observed [9]. These clinical facts can be explained by the almost rectilinear path of the carotid artery, whereas the common femoral artery and its branches show a tortuous path [9]. Indeed, our work shows, through a statistical correlation, that the tortuosity of the common femoral artery has an influence on its atheromatous calcification.…”

Section: Discussionmentioning

confidence: 50%

“…A comparative study on the symmetry between the carotid artery and the femoral bifurcation, concerning the deposition of atheromatous plaques, shows perfect symmetry at the carotid level. On the other hand, at the femoral bifurcation, asymmetry of atheromatous plaques is observed [9]. These clinical facts can be explained by the almost rectilinear path of the carotid artery, whereas the common femoral artery and its branches show a tortuous path [9].…”

Section: Discussionmentioning

confidence: 99%

The Configuration of the Femoral Arterial Bifurcation’s Influence on Its Atherogenesis

Gaye¹,

Dieng²,

Ndiaye³

et al. 2020

FMAR

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Several theories point to the influence of the geometry of femoral arterial bifurcation in the formation and evolution of atherosclerosis plaques at the level of common, superficial and deep femoral arteries. The objective of this study is to correlate the degrees of calcifications of the femoral tripod with different morphological parameters, namely conicity, tortuosity, proximal and distal diameters of the arteries and angles between the common femoral artery (CFA) and the superficial femoral artery (SFA) and the profound femoral artery (PFA) and the superficial femoral artery. The results showed that only the tortuosity of the common femoral artery influences the formation of atherosclerosis plaque. These results allow us to predict the degree of calcification of the femoral tripod based on the tortuosity of the common femoral artery.

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“…These results seem to suggest that genetic factors, rather than other factors shared by twins (such as constitutional or local factors, e.g. vessels' angulation) [29], are involved in the occurrence of atherosclerotic plaques and probably in the atherogenic process itself. However, it cannot be excluded that specific genetic or environmental risk factors could affect different vascular territories.…”

Section: Discussionmentioning

confidence: 87%

Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

Lucatelli

Fagnani

Tárnoki

et al. 2017

Int J Cardiovasc Imaging

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To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.

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Asymmetry in prevalence of femoral but not carotid atherosclerosis

Cited by 14 publications

References 29 publications

Femoral Artery Ultrasound Examination

Femoral Artery Ultrasound Examination

The Configuration of the Femoral Arterial Bifurcation’s Influence on Its Atherogenesis

Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study

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