“…A possibility to address this problem is to treat the methyl group as a rigid symmetric rotor with local C 3 v symmetry (see Table S2). However, the results will be not realistic because the neighbor group to which the methyl group is attached, the C α N′C′H α group, does not have 3-fold symmetry. On the other hand, for other AA residues, all except glycine and alanine, it is necessary to fix the χ 1 angle (N′–C α –C β –X γ ), choosing an X γ substituent.…”