Asymmetrische Totalsynthese und Festkörperstruktur des marinen cytotoxischen Diterpens (+)‐Vigulariol

Collective Synthesis of Cladiellins Based on the Gold‐Catalyzed Cascade Reaction of 1,7‐Diynes

“…9f, 12, 15 The spectroscopic data ( 1 H and 13 C NMR spectra, HRMS analyses, and optical rotation) of the synthesized samples of 1 , 2 , 5 , and 6 were in good agreement with those reported for the corresponding natural materials 9f. 12, 13, 15…”

Collective Synthesis of Cladiellins Based on the Gold‐Catalyzed Cascade Reaction of 1,7‐Diynes

“…[5] Despite these reports, the antitumor and antimicrobial activities of the many other compounds belonging to the cladiellin family have not been extensively evaluated. [7][8][9][10][11][12][13][14][15] In fact, research into the total synthesis of cladiellins has played an important role in determining their structures. [6] Several members of the cladiellin family have been successfully synthesized by a number of research groups.…”

“…[6] Several members of the cladiellin family have been successfully synthesized by a number of research groups. [7][8][9][10][11][12][13][14][15] In fact, research into the total synthesis of cladiellins has played an important role in determining their structures. [7, 8, 9e] The tricyclic compound 10 has been used as a common latestage intermediate in a number synthetic strategies for accessing various cladiellins, including 1, 2, 5, and 6.…”

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

“…[5] By using computer-guided substructure searches, it is relatively easy to identify molecules that partially overlap with the target structure, differing only in the oxidation state or the degree of unsaturation. As a result of rapid progress in oxidative C À H functionalizations, [6,7] terpenes from plant oil [8] will gain importance as sustainable feedstock in synthesis.…”