Asymmetries of cerebral perfusion in a stroke-age population

Baird, Alison E.; Donnan, Geoffrey A; Austin, Mark C.; Hennessy, Oliver; Royle, J P; McKay, W J

doi:10.1016/s0967-5868(99)90075-9

Cited by 10 publications

(13 citation statements)

References 12 publications

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“…Catafau et al (1996) showed a mixed left-right pattern of asymmetry in a cohort of control subjects of similar age to our ECD group, and a stronger rightward pattern in a much older cohort, suggesting that SPECT laterality becomes progressively rightward with increasing subject age. Other prior reports of rightward laterality with HMPAO or ECD SPECT tracers used subjects significantly older than (Baird et al, 1999;Lobaugh et al, 2000), or spanning a larger age range (Van Laere et al, 2001;Markus et al, 1993;Grova et al, 2003) than our cohort. Krausz et al (1998) showed a mixed pattern of laterality in a group of subjects spanning a wide range of ages.…”

Section: Discussionmentioning

confidence: 74%

“…Prior studies investigating lateral asymmetry in SPECT images of normal brain have used visual comparison (Aubert-Broche et al, 2005), manually placed or drawn region of interest (ROI) measurements (Markus et al, 1993;Catafau et al, 1996;Baird et al, 1999;Grova et al, 2003;Aubert-Broche et al, 2005), template-based ROI measurements (Krausz et al, 1998;Van Laere et al, 2001) or a two-compartment model (Risberg et al, 1975) to assess asymmetry. Prior studies have not, however, provided a comprehensive picture of the patterns of SPECT asymmetry.…”

Section: Introductionmentioning

confidence: 99%

“…Functional lateralization is one of the foundations of brain organization, and is well documented through lesion studies (Brain, 1941;Rasmussen and Milner, 1977), direct electrical stimulation of cortex (Penfield and Jasper, 1954), and intracarotid sodium amytal testing (Wada et al, 1975), with language functions typically residing in the left hemisphere and showing a strong correlation with planum temporale size and right handedness (Foundas et al, 1995). Prior studies investigating lateral asymmetry in SPECT images of normal brain have used visual comparison (Aubert-Broche et al, 2005), manually placed or drawn region of interest (ROI) measurements (Markus et al, 1993;Catafau et al, 1996;Baird et al, 1999;Grova et al, 2003;Aubert-Broche et al, 2005), template-based ROI measurements (Krausz et al, 1998;Van Laere et al, 2001) or a two-compartment model (Risberg et al, 1975) to assess asymmetry. Prior studies have not, however, provided a comprehensive picture of the patterns of SPECT asymmetry.…”

Section: Introductionmentioning

confidence: 99%

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Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Brinkmann

Jones

Stead

et al. 2011

J Cereb Blood Flow Metab

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Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Brinkmann

Jones

Stead

et al. 2011

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Previous data suggest age-related metabolic decreases in the middle and superior temporal cortex, albeit less pronounced than in frontal regions, which were related to white matter disturbances in the long association fronto-temporo-occipital fibers [Chetelat et al, 2013]. At the same time, hemispheric perfusion seems to be asymmetric in the superior temporal cortex, i.e., right higher than left [Baird et al, 1999]. The lack of apparent functional-structural relationship evident by our functional decoding and MACM analyses, which are in contrast to the superior temporal peak found in the asymmetry analysis in AD, might point to failed convergence of data resulting from a slightly different ROI positioning and/or an asymmetric pattern resulting merely from structural dislocations due to a shift in the GM-white matter boundary following loss of myelin.…”

Section: Healthy Agingmentioning

confidence: 96%

Gray matter asymmetries in aging and neurodegeneration: A review and meta‐analysis

Minkova

Habich

Peter

et al. 2017

Human Brain Mapping

153

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Inter-hemispheric asymmetries are a common phenomenon of the human brain. Some evidence suggests that neurodegeneration related to aging and disease may preferentially affect the left-usually language- and motor-dominant-hemisphere. Here, we used activation likelihood estimation meta-analysis to assess gray matter (GM) loss and its lateralization in healthy aging and in neurodegeneration, namely, mild cognitive impairment (MCI), Alzheimer's dementia (AD), Parkinson's disease (PD), and Huntington's disease (HD). This meta-analysis, comprising 159 voxel-based morphometry publications (enrolling 4,469 patients and 4,307 controls), revealed that GM decline appeared to be asymmetric at trend levels but provided no evidence for increased left-hemisphere vulnerability. Regions with asymmetric GM decline were located in areas primarily affected by neurodegeneration. In HD, the left putamen showed converging evidence for more pronounced atrophy, while no consistent pattern was found in PD. In MCI, the right hippocampus was more atrophic than its left counterpart, a pattern that reversed in AD. The stability of these findings was confirmed using permutation tests. However, due to the lenient threshold used in the asymmetry analysis, further work is needed to confirm our results and to provide a better understanding of the functional role of GM asymmetries, for instance in the context of cognitive reserve and compensation. Hum Brain Mapp 38:5890-5904, 2017. © 2017 Wiley Periodicals, Inc.

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“…Only relative quantification can be used, for example using regions of interest (ROIs). ROIs may be geometric [2] or may follow the boundaries of anatomical structures [3]. They may be positioned manually or with the assistance of an anatomical atlas or template [4] or of the Magnetic Resonance images (MR) of the patient [5].…”

Section: Introductionmentioning

confidence: 99%

Detection of Inter-hemispheric Asymmetries of Brain Perfusion in SPECT

Aubert-Broche

Grova

Jannin

et al. 2002

Medical Image Computing and Computer-Assisted Intervention — MICCAI 2002

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Abstract. This paper describes an unsupervised method to help detection of significant functional inter-hemispheric asymmetries in brain SPECT. A validation of this method was performed with realistic simulated SPECT data sets with known asymmetries (in size and amplitude) as gold standard. Detection performances were assessed through Receiver Operating Characteristic (ROC) analysis based on measures of the overlap between known and detected asymmetries.

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Asymmetries of cerebral perfusion in a stroke-age population

Cited by 10 publications

References 12 publications

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Gray matter asymmetries in aging and neurodegeneration: A review and meta‐analysis

Detection of Inter-hemispheric Asymmetries of Brain Perfusion in SPECT

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