Asymmetrical state dependency from temporary septal area dysfunction in rats.

Duncan, Perry M.; Copeland, Marc

doi:10.1037/h0077448

Cited by 2 publications

(1 citation statement)

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“…We observed asymmetry of state-dependent learning on GBX referring to the much greater effect of GBX to recover freezing in GBX-conditioned mice than to impair freezing in Veh-conditioned mice. This finding is consistent with previously observed asymmetry in state-dependent memory (Duncan and Copeland 1975). This asymmetry could be due to the fact that the retrievalrelated processes, such as reconsolidation or extinction, during the Veh test that could render the Veh-conditioned group less sensitive to GBX actions.…”

Section: Discussionsupporting

confidence: 93%

Neurobiological correlates of state-dependent context fear

et al. 2017

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Retrieval of fear memories can be state-dependent, meaning that they are best retrieved if the brain states at encoding and retrieval are similar. Such states can be induced by activating extrasynaptic γ-aminobutyric acid type A receptors (GABAR) with the broad α-subunit activator gaboxadol. However, the circuit mechanisms and specific subunits underlying gaboxadol's effects are not well understood. Here we show that gaboxadol induces profound changes of local and network oscillatory activity, indicative of discoordinated hippocampal-cortical activity, that were accompanied by robust and long-lasting state-dependent conditioned fear. Episodic memories typically are hippocampus-dependent for a limited period after learning, but become cortex-dependent with the passage of time. In contrast, state-dependent memories continued to rely on hippocampal GABAergic mechanisms for memory retrieval. Pharmacological approaches with α-subunit-specific agonists targeting the hippocampus implicated the prototypic extrasynaptic subunits (α) as the mediator of state-dependent conditioned fear. Together, our findings suggest that continued dependence on hippocampal rather than cortical mechanisms could be an important feature of state-dependent memories that contributes to their conditional retrieval.

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Section: Discussionsupporting

confidence: 93%