Asymmetric Wettable, Waterproof, and Breathable Nanofibrous Membranes for Wound Dressings

Yao, Yueming; Guo, Yixuan; Li, Xiaoran; Yu, Jianyong; Ding, Bin

doi:10.1021/acsabm.0c01624

Cited by 30 publications

(11 citation statements)

References 42 publications

(67 reference statements)

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“…17 The wound dressing with optimal WVTR could prevent dehydration, and control water loss to create an environment with an ideal moisture level for wound healing. [35][36][37] Figure 3(c) shows the WVTR of the CS sponge, PCL membrane, and CS-PCL composite dressing. The WVTR of the control and hydrophilic surface was 5079 and 4664 g m À2 day À1 , respectively.…”

Section: Asymmetric Wettability Water Vapor Transmission Rate and Deg...mentioning

confidence: 99%

An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing

et al. 2022

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An effective dressing is essential for wound healing. In fact, the wettability performance is one of the most important factors of a wound dressing. The fundamental functions of a wound dressing involve the absorption of excess exudates and maintenance of optimal moisture at the wound by controlling water evaporation. Here, we designed a type of chitosan (CS) sponge and PCL nanofibrous membrane composite dressing with asymmetric wettability surfaces as wound healing materials for biomedical applications. The hydrophobic surfaces of the composite dressing were waterproof and could efficiently control the water vapor transmission rate, whereas the hydrophilic surface of the CS sponge had good cytocompatibility and water-absorbing capability. Insulin-like growth factor-2 (IGF-2) was added to the CS sponge, and exhibited a stimulatory effect on fibroblasts migration and proliferation. Therefore, the fabricated CS sponge and PCL membrane composite dressing had excellent cytocompatibility, vapor transmission rate, and liquid absorption and asymmetric wettability, suggesting its potential as a promising alternative to traditional wound dressing.

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Section: Asymmetric Wettability Water Vapor Transmission Rate and Deg...mentioning

confidence: 99%

An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing

et al. 2022

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“…The size is usually considered as the distance between two adjacent cross‐linking junctions. [ 25 ] The height of the detected nanopores on PDMS surface is ≈15 ± 5 nm. Such interconnected morphology and porous structures impart the membrane's excellent moisture vapor permeability and make it an ideal wound dressing material.…”

Section: Resultsmentioning

confidence: 99%

Engineered Sandwich‐Structured Composite Wound Dressings with Unidirectional Drainage and Anti‐Adhesion Supporting Accelerated Wound Healing

Wang

Duan

Ren

et al. 2022

Adv Healthcare Materials

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Proper management of exudate is of great clinical value for reducing wound infection and promoting wound healing, thus various dressings have been studied to address this widespread medical challenge. Herein, a novel sandwich‐structured composite wound dressing (SCWD), integrating of a superlyophobic (SLO) polydimethylsiloxane (PDMS) layer, a superlyophilic gauze layer, and a lyophobic PDMS layer is presented, with particular unidirectional droplet drainage and stable anti‐adhesion capabilities, which realizes effective management of wound exudate and provides a favorable environment for wound healing. Thanks to the stable SLO property on the PDMS surface with hierarchical micro/nanostructures, the continuously accumulated wound exudate at the interface between dressing and wound surface is gradually deformed, eventually passing through SLO PDMS layer through milli‐scale channels and being absorbed by gauze layer. Experimental results show that the application of SCWD can significantly reduce the occurrence of wound infection, avoid the tearing of wound tissues when replacing dressings, and accelerate wound healing by ≈20%. The combination of SCWD and lyophilized powders of stem cells supernatant (LPSCS) is verified to better accelerate the healing process. The proposed method offers great potential in clinical applications, particularly for acute trauma wound treatments.

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“…Similarly, another group of researchers developed an asymmetric wettable gradient nanofibrous membrane, consisting of polyvinyl butyral (PVB)-polydimethylsiloxane (PDMS) as the top layer followed by a layer of PVB-PDMS/gelatin and gelatin as a hydrophilic layer [ 155 ]. The upper layer showed a better contact angle (CA) than the gelatin lower layer.…”

Section: Electrospun Nf Implantsmentioning

confidence: 99%

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

et al. 2022

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Electrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF's pros is to provide a controlled drug release through managing the NF structure by changing the spinneret type and nature of the used polymer. Electrospun NFs are employed as implants in several applications including, cancer therapy, microbial infections, and regenerative medicine. These implants facilitate a unique local delivery of chemotherapy because of their high loading capability, wide surface area, and cost-effectiveness. Multi-drug combination, magnetic, thermal, and gene therapies are promising strategies for improving chemotherapeutic efficiency. In addition, implants are recognized as an effective antimicrobial drug delivery system overriding drawbacks of traditional antibiotic administration routes such as their bioavailability and dosage levels. Recently, a sophisticated strategy has emerged for wound healing by producing biomimetic nanofibrous materials with clinically relevant properties and desirable loading capability with regenerative agents. Electrospun NFs have proposed unique solutions, including pelvic organ prolapse treatment, viable alternatives to surgical operations, and dental tissue regeneration. Conventional ES setups include difficult-assembled mega-sized equipment producing bulky matrices with inadequate stability and storage. Lately, there has become an increasing need for portable ES devices using completely available off-shelf materials to yield highly-efficient NFs for dressing wounds and rapid hemostasis. This review covers recent updates on electrospun NFs in nanomedicine applications. ES of biopolymers and drugs is discussed regarding their current scope and future outlook.

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Asymmetric Wettable, Waterproof, and Breathable Nanofibrous Membranes for Wound Dressings

Cited by 30 publications

References 42 publications

An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing

An asymmetric wettable PCL/chitosan composite scaffold loaded with IGF-2 for wound dressing

Engineered Sandwich‐Structured Composite Wound Dressings with Unidirectional Drainage and Anti‐Adhesion Supporting Accelerated Wound Healing

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

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