Asymmetric Transfer Hydrogenation of Stable NH Imines for the Synthesis of Enantiopure α‐Chiral Primary Amines
Mangang Zhang,
Hui Li,
Keqin Wu
et al.
Abstract:Comprehensive SummaryAlthough it offers a direct route to access synthetically valuable α‐chiral primary amines, asymmetric transfer hydrogenation of NH imines has been rarely studied, due in large part to the inaccessibility and instability of NH imines. Herein, we report a Rh‐catalyzed asymmetric transfer hydrogenation of a kind of novel and stable NH imines which are prepared via condensation of easily available sulfonylated 2’‐aminoacetophenones with NH3 in methanol. With this method, enantioenriched chira… Show more
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