Asymmetric transfer hydrogenation of ketones catalyzed by chiral macrocyclic cobalt(II) complexes

Ruan, Sun-Hong; Fan, Ziwei; Zhang, Wenjing; Han, Xu; An, Dongli; Wei, Ziheng; Yuan, Ruming; Gao, Jingxiang; Li, Yanyun

doi:10.1016/j.jcat.2023.01.008

Cited by 10 publications

(1 citation statement)

References 72 publications

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“…Asymmetric transfer hydrogenation of ketones using a Co/ macrocyclic ligand complex. [91] Scheme 43. Metal charge directed enantiodivergent asymmetric ketone hydrogenation.…”

Section: C=o Hydrogenationmentioning

confidence: 99%

Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Chakrabortty,

de Bruin,

de Vries

2023

Angew Chem Int Ed

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Asymmetric hydrogenation finds widespread application in academia and industry. And indeed, a number of processes have been implemented for the production of pharma and agro intermediates as well as flavors & fragrances. Although these processes are all based on the use of late transition metals as catalysts, there is an increasing interest in the use of base metal catalysis in view of their lower cost and the expected different substrate scope. Catalysts based on cobalt have already shown their potential in enantioselective hydrogenation chemistry. This review outlines the impressive progress made in recent years on cobalt‐catalyzed asymmetric hydrogenation of different unsaturated substrates. We also illustrate the ligand dependent substrate specificity as well as the mechanistic variability in detail. This may well guide further catalyst development in this research area.

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“…Asymmetric transfer hydrogenation of ketones using a Co/ macrocyclic ligand complex. [91] Scheme 43. Metal charge directed enantiodivergent asymmetric ketone hydrogenation.…”

Section: C=o Hydrogenationmentioning

confidence: 99%

Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Chakrabortty,

de Bruin,

de Vries

2023

Angew Chem Int Ed

View full text Add to dashboard Cite

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Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Chakrabortty,

de Bruin,

de Vries

2023

Angewandte Chemie

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Organometallic Mn(I) Complexes in Asymmetric Catalytic (Transfer) Hydrogenation and Related Transformations

Fu,

Wang,

Liu

et al. 2024

ChemCatChem

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Direct asymmetric hydrogenation (AH) and asymmetric transfer hydrogenation (ATH) reactions are among the most efficient approaches to produce chiral building blocks. Recently, these types of transformations have witnessed a shift towards the use of molecular catalysts based on earth‐abundant transition metals due to their ready availability, economic advantage, and novel properties. With particular regard to manganese, catalyst development has seen both the efficiency and substrate scope in AH and ATH greatly improved, with the emergence of a large number of well‐defined Mn‐complexes employed in this field. The reaction scope includes the AH and ATH of C=O bonds, asymmetric reduction of C=N bonds and the asymmetric reductive transformations of C=C bonds. Herein, our survey of the area focuses on the catalytic activity of such complexes, their versatility towards asymmetric transformations and the routes employed to convert substrates to their target molecules. We consider the collected findings of this article will be helpful to the reader by providing an insight into ligand design, thereby aiding future catalyst development. Moreover, this review is aimed at highlighting the remarkable progress made in the last six years in the development of manganese complexes for enantioselective reduction.

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Asymmetric transfer hydrogenation of ketones catalyzed by chiral macrocyclic cobalt(II) complexes

Cited by 10 publications

References 72 publications

Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Cobalt‐Catalyzed Asymmetric Hydrogenation: Substrate Specificity and Mechanistic Variability

Organometallic Mn(I) Complexes in Asymmetric Catalytic (Transfer) Hydrogenation and Related Transformations

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