Abstract:Asymmetric total synthesis of neobraclactone C was finished
for
the first time using the convergent synthetic strategy in 22 steps
in the longest linear sequence from known materials. The key steps
include a steric hindrance/hydrogen bond dual-controlled Heck arylation
of α,β-unsaturated ketone to construct hemiketal and cis-alkenyl in one step and a CeCl3-catalyzed
tricycle formation.
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