Asymmetric Total Synthesis of Complex Marine Natural Products

Reaction of selenium and tellurium halides with propargyl alcohols. The regio‐ and stereoselectivity of addition to the triple bond

“…Spiroketals are molecular frameworks found in a variety of complex natural products that possess a wide range of biological activities 50–57. Promising pharmacological effects (such as phosphatase inhibition, modulation of the tubulin cytoskeleton of breast cancer cells, and cytotoxic against tumor cell lines) have been discovered in the course of screening of simple spiroketals 58–67.…”

Applications of oxazolidinones as chiral auxiliaries in the asymmetric alkylation reaction applied to total synthesis

“…It is an ever growing important strategy in modern synthetic organic chemistry particularly in the total synthesis of biologically active natural products. 42 In general, there are two strategies for the synthesis of enantio-and diastereomeric pure organic compounds. The rst approach is to employ a resolution step, a so-called racemic modication.…”

The chemistry and biology of organic guanidine derivatives

“…174 The review ''The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels'' presented several aspects of tetrodotoxin (TTX) interactions with Na-channels, including the TTX (43) blockage of gene expression of the sodium channel gene family, the interactions of TTX with both Na-channel and Na-channel gate at the molecular level, physiological effects of TTX and mechanisms of TTX resistance, 175 while the review ''Asymmetric total synthesis of complex marine natural products'' included the synthetic approaches toward TTX developed by Kishi and Isobe. 176 The review ''Enzyme inhibitors and other bioactive compounds from marine actinomycetes'' include mentions to the occurrence of TTX in various actinomycetes. 177 Not included in our previous review 1 was the report that the garter snakes Thamnopsis couchii and T. sirtalis from California (USA) acquired resistance to TTX and feed on the newt Taricha torosa, but not the same species from North America.…”