Asymmetric Synthesis of α‐Amino Acids Bearing a 3‐Alkyloxindole Structural Motif

Abstract

We report a diastereoselective Mannich-type reaction of 3alkyloxindole with N-tert-butanesulfinyl imino ester. This method provides a concise route to α-amino acid derivatives bearing a 3-alkyloxindole structural motif. This protocol has the advantage of using readily accessible starting materials and is operationally simple. A plausible transition-state mode for the observed stereoselectivity is presented.