Asymmetric synthesis of spirocyclic isobenzofuranones via a squaramide-catalysed sulfa-Michael desymmetrisation reaction

Abstract

Enantioselective syntheses of spirocyclohexenone-isobenzofuranones have been achieved through an organocatalyzed sulfa-Michael desymmetrization reaction. A cinchona-derived squaramide effectively promotes the desymmetrization of spirocyclic 2,5-cyclohexadienone isobenzofuranones via the controlled addition of various...