“…Still in the laboratory context, in addition to the food area, this biotechnology has been explored in clinical and pharmacological issues, as a promising technique in the search for biological routes in the identification of pathogenic microorganisms in exams (SOUZA; COBERLLINI, 2019) or playing a role as a method of obtaining metabolites that may act as potential new drugs, such as, for example, in the biotransformation processes of antiasthmatic drugs (AHMAD et al, 2014), anthelmintics (BARTH et al, 2015), antidepressants (OLIVEIRA et al, 2015(OLIVEIRA et al, ) al., 2015 or compounds with antimicrobial activity (GRABARCZYK et al, 2013). This biotechnology has also been linked to genetic and biochemical issues, evaluating the alterations that secondary metabolites, dispersed in the environment, It must be mentioned that concomitant biotransformation has also been addressed at the intersection of activities in the food industry and industrial innovations.…”
Section: General Aspects Of Microbial Biotransformation Approachesmentioning
confidence: 99%
“…Aspergillusniger are fungi that, through fermentation processes, can hydrolyze steroid compounds, transforming them into interesting metabolites for further studies (AHMAD et al, 2014). such as Penicillium crustosum, Aspergillus fumigatus, Nigrospora sphaerica, Papulaspora immerse, Papulaspora immera Hotson and Mucor rouxii demonstrate that microorganisms can be used as biocatalytic agents in obtaining new drugs (BARTH et al, 2015;OLIVEIRA et al, 2015). Source: Own authorship.…”
Section: Techniques and Bioprocessesmentioning
confidence: 99%
“…The processes involving microbial biotransformation demonstrate the efficiency brought about by the use of this technology, both in time and quality, as well as in environmental issues. From a chemical point of view, processes that involve numerous steps for the chemical synthesis of new compounds can be reduced in number of steps, procedures, reagents and drastic conditions when using microbial biotransformation (BARTH et al, 2015). Thus, a reduction in the amount of hazardous substances involved or even their complete elimination from the synthesis processes of new metabolites can be observed, calling biotransformation green chemistry (AHMAD et al 2014).…”
Biological and Natural Sciencesv. 2, n. 8, 2022 All content in this magazine is licensed under a Creative Commons Attribution License. Attribution-Non-Commercial-Non-Derivatives 4.0 International (CC BY-NC-ND 4.0).
“…Still in the laboratory context, in addition to the food area, this biotechnology has been explored in clinical and pharmacological issues, as a promising technique in the search for biological routes in the identification of pathogenic microorganisms in exams (SOUZA; COBERLLINI, 2019) or playing a role as a method of obtaining metabolites that may act as potential new drugs, such as, for example, in the biotransformation processes of antiasthmatic drugs (AHMAD et al, 2014), anthelmintics (BARTH et al, 2015), antidepressants (OLIVEIRA et al, 2015(OLIVEIRA et al, ) al., 2015 or compounds with antimicrobial activity (GRABARCZYK et al, 2013). This biotechnology has also been linked to genetic and biochemical issues, evaluating the alterations that secondary metabolites, dispersed in the environment, It must be mentioned that concomitant biotransformation has also been addressed at the intersection of activities in the food industry and industrial innovations.…”
Section: General Aspects Of Microbial Biotransformation Approachesmentioning
confidence: 99%
“…Aspergillusniger are fungi that, through fermentation processes, can hydrolyze steroid compounds, transforming them into interesting metabolites for further studies (AHMAD et al, 2014). such as Penicillium crustosum, Aspergillus fumigatus, Nigrospora sphaerica, Papulaspora immerse, Papulaspora immera Hotson and Mucor rouxii demonstrate that microorganisms can be used as biocatalytic agents in obtaining new drugs (BARTH et al, 2015;OLIVEIRA et al, 2015). Source: Own authorship.…”
Section: Techniques and Bioprocessesmentioning
confidence: 99%
“…The processes involving microbial biotransformation demonstrate the efficiency brought about by the use of this technology, both in time and quality, as well as in environmental issues. From a chemical point of view, processes that involve numerous steps for the chemical synthesis of new compounds can be reduced in number of steps, procedures, reagents and drastic conditions when using microbial biotransformation (BARTH et al, 2015). Thus, a reduction in the amount of hazardous substances involved or even their complete elimination from the synthesis processes of new metabolites can be observed, calling biotransformation green chemistry (AHMAD et al 2014).…”
Biological and Natural Sciencesv. 2, n. 8, 2022 All content in this magazine is licensed under a Creative Commons Attribution License. Attribution-Non-Commercial-Non-Derivatives 4.0 International (CC BY-NC-ND 4.0).
“…The costs associated with the purification of enzymes also disappear. It is also extremely important that some microorganisms can simulate the metabolism of mammalian cytochrome P450 monooxygenases (CYPs) [13][14][15][16][17].…”
Section: Biotransformations In Cultures Of Microorganismsmentioning
The production of chiral sulphoxides is an important part of the chemical industry since they have been used not only as pharmaceuticals and pesticides, but also as catalysts or functional materials. The main purpose of this review is to present biotechnological methods for the oxidation of sulfides. The work consists of two parts. In the first part, examples of biosyntransformation of prochiral sulfides using whole cells of bacteria and fungi are discussed. They have more historical significance due to the low predictability of positive results in relation to the workload. In the second part, the main enzymes responsible for sulfoxidation have been characterized such as chloroperoxidase, dioxygenases, cytochrome flavin-dependent monooxygenases, and P450 monooxygenases. Particular emphasis has been placed on the huge variety of cytochrome P450 monooxygenases, and flavin-dependent monooxygenases, which allows for pure sulfoxides enantiomers effectively to be obtained. In the summary, further directions of research on the optimization of enzymatic sulfoxidation are indicated.
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