Asymmetric stem cell division: Lessons from Drosophila

Stem cells, the current state of researches on this problem and the main directions of their development. From theory to clinical practice

“…Благодаря АДСК происходит самообновление СК, сохраняющих эту способность на протяжении всей жизни и поддерживающих общее количе-ственное постоянство и вместе с тем равновесие как резерва СК, так и восполнение популяции дифференцированных клеток, что не менее важно для поддержания гомеостатического статуса орга-низма [9].…”

Control of neural stem cell self-renewal and differentiation in Drosophila

“…In the central brain and in the thoracic ganglia, most embryonic neuroblasts enter quiescence in the late embryonic stage (Egger et al, 2008;Younossi-Hartenstein et al, 1996). Exceptions are the four neuroblasts that generate the intrinsic neurons of the mushroom body, along with a fifth brain neuroblast, which do not undergo quiescence, and divide continuously throughout all larval stages to generate exceptionally large lineages of neurons in adult CNS.…”

“…Kambadur et al, 1998;Karlsson et al, 2010;Reichert, 2011;Touma et al, 2012;Tran and Doe, 2008). Indeed, many of the basic cellular processes and molecular mechanisms that operate in asymmetric stem cell division have been elucidated in the Drosophila neuroblast models (Januschke and Gonzalez, 2008;Schaefer and Knoblich, 2001;Wu et al, 2008;Zhong and Chia, 2008). While type I and type II neuroblasts differ in some aspects of their asymmetric cell division modes, a fundamental property of the asymmetric divisions manifested by these neuroblasts is the unequal segregation of proteins that assign cell polarity and cell fate to the two asymmetric daughter cells, the selfrenewing neuroblast and the more differentiated daughter cell (GMC or INP) (Doe, 2008;Homem and Knoblich, 2012;Neumuller and Knoblich, 2009).…”

Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart?

“…Research focused on Drosophila stem cells has been instrumental in characterizing basic mechanisms of stem cell regulation, including the interactions between stem cells and their niche [10][11][12] and the role of asymmetric divisions in controlling stem cell behavior (reviewed in 13,14 ). In addition, more recent work has underscored the use of Drosophila as an excellent model system to explore the response of stem cells to various forms of physiological, metabolic and genotoxic stress, from infections to starvation and aging.…”