Asymmetric split-ring resonator-based biosensor for detection of label-free stress biomarkers

Lee, Hee Jo; Lee, Jung Hyun; Choi, Suji; Jang, Ik Soon; Choi, Jong Soon; Jung, Hyo Il

doi:10.1063/1.4816440

Cited by 62 publications

(30 citation statements)

References 23 publications

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“…As Figure 10 shows, Lee et al exhibited various SRR-based biomarker sensors with different patterns, such as symmetric single ring, double ring and asymmetric single ring. In their works, the frequency shifts were obtained at different concentrations of biomarkers and calculated to show excellent results for the detection of PSA, cortisol, and alpha-amylase, respectively [ 155 – 157 ]. Due to the tunable plasmonic metamaterial provided double-channel for both optical and SERS transmissions in Cao et al's work, the sensor could monitor conformational states and binding affinity of biomolecules simultaneously.…”

Section: Microstructure-based Biomarker Sensorsmentioning

confidence: 99%

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Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Section: Microstructure-based Biomarker Sensorsmentioning

confidence: 99%

“…These sensors were all based on SRR and its derived structures, and the concentrations of biomarkers can be obtained by measuring the drifts of resonance frequency. Reproduced from Lee et al [ 155 – 157 ] with permissions.…”

Section: Figurementioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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“…The SRR basically work as an LC resonator. The SRR resonates at its magnetic resonance frequency, when it is excited by a time varying magnetic field [6], [8]. When the time varying magnetic field penetrates the SRR, currents are induced in the rings and flow in the same direction [9].…”

Section: A Split Ring Resonatormentioning

confidence: 99%

“…The main characteristic of SRR is its very small electrical size, due to this; they are widely used from microwave to terahertz frequency range. In the past, split ring resonators have been used for the sensing of glucose content in blood plasma [4], DNA sensing [5], detection of label free stress biomarkers [6] and for ethanol and petrol sensing [7]. In this work, we have used split ring resonator as sensor to detect the quality of water whether it is fresh water, distilled water or sea water.…”

Section: Introductionmentioning

confidence: 99%

Detection of Water Quality using Defected Ground Double Split Ring Resonator

Kumar*,

Bhushan

2019

IJRTE

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Water is an essential thing for life. Now days due to population growth and pollution, the quality of water is degraded. In this paper, a single element double split ring resonator (DSRR) has been presented as a sensor to detect the quality of water. Here, two square shape metallic split rings are designed along with the microstrip line. On the back side of the substrate, defected ground structure (DGS) is introduced. The resonant frequency of the resonator is 11.12 GHz. Quality of water is detected by the shift in S21 resonant frequency with the variation in transmission coefficient. This sensor can be used in our daily life to detect the quality of water and it may be useful in medical field also

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“…However, this spectroscopy method requires longer stabilization times and is affected by the tissue density, tissue thickness and hematocrit. Recently, radiofrequency (RF)-based label-free biosensors for use in applications, such as the detection of stress biomarkers 18 , biomolecular binding 19 20 , human cell dielectric spectroscopy 21 , and glucose detection 22 23 24 25 26 have been reported. Glucose sensors based on this technique quantitatively assess glucose levels by observing the level of electromagnetic coupling, which depends on glucose permittivity.…”

mentioning

confidence: 99%

Rapid, Sensitive and Reusable Detection of Glucose by a Robust Radiofrequency Integrated Passive Device Biosensor Chip

Kim

Adhikari

Chuluunbaatar

et al. 2015

Sci Rep

136

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Tremendous demands for sensitive and reliable label-free biosensors have stimulated intensive research into developing miniaturized radiofrequency resonators for a wide range of biomedical applications. Here, we report the development of a robust, reusable radiofrequency resonator based integrated passive device biosensor chip fabricated on a gallium arsenide substrate for the detection of glucose in water-glucose solutions and sera. As a result of the highly concentrated electromagnetic energy between the two divisions of an intertwined spiral inductor coupled with an interdigital capacitor, the proposed glucose biosensor chip exhibits linear detection ranges with high sensitivity at center frequency. This biosensor, which has a sensitivity of up to 199 MHz/mgmL−1 and a short response time of less than 2 sec, exhibited an ultralow detection limit of 0.033 μM and a reproducibility of 0.61% relative standard deviation. In addition, the quantities derived from the measured S-parameters, such as the propagation constant (γ), impedance (Z), resistance (R), inductance (L), conductance (G) and capacitance (C), enabled the effective multi-dimensional detection of glucose.

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Asymmetric split-ring resonator-based biosensor for detection of label-free stress biomarkers

Cited by 62 publications

References 23 publications

Recent Progress of Biomarker Detection Sensors

Recent Progress of Biomarker Detection Sensors

Detection of Water Quality using Defected Ground Double Split Ring Resonator

Rapid, Sensitive and Reusable Detection of Glucose by a Robust Radiofrequency Integrated Passive Device Biosensor Chip

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